Kmieciak-Kołada K, Felińska W, Stachura Z, Majchrzak H, Herman Z S
Department of Clinical Pharmacology, Silesian Medical Academy, Katowice, Poland.
Pol J Pharmacol Pharm. 1987 Jan-Feb;39(1):47-53.
The levels of biogenic amines and their metabolites were determined in different parts of brain or cerebral-spinal fluid 0.5, 1, 6, 12 or 24 h after experimental cerebral concussion. Cerebral concussion in the rat leads within 6 h to an increase in 5-hydroxytryptamine and a decrease in dopamine utilization in the striatum. That imbalance between the functional state of serotoninergic and dopaminergic neurons may partly explain the development of vasospasms, ischemia and edema brought about by the brain mechanical trauma. Moreover, after cerebral concussion an evident decrease in NA level in discrete brain areas and a decreased DA release in the whole brain occur. In conclusion it is suggested that the alterations of catecholamine and 5-hydroxytryptamine utilization in discrete brain areas, especially in the striatum are the characteristic feature of disturbances after experimental brain concussion.
在实验性脑震荡后0.5、1、6、12或24小时，测定大脑不同部位或脑脊液中生物胺及其代谢物的水平。大鼠脑震荡后6小时内，纹状体中5-羟色胺增加，多巴胺利用减少。血清素能和多巴胺能神经元功能状态之间的这种失衡可能部分解释了脑机械创伤引起的血管痉挛、缺血和水肿的发生。此外，脑震荡后，离散脑区的去甲肾上腺素水平明显降低，全脑多巴胺释放减少。总之，提示离散脑区，尤其是纹状体中儿茶酚胺和5-羟色胺利用的改变是实验性脑震荡后功能障碍的特征性表现。
