Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland, 22 S Greene St, Sixth Floor, Room 6NW 104K, Baltimore, MD 21201 USA.
J Ultrasound Med. 2014 Feb;33(2):329-36. doi: 10.7863/ultra.33.2.329.
The purpose of this study was to establish reference ranges for ductus venosus velocity ratios.
Singleton pregnancies from 11 to 38 weeks with exactly established gestational ages (GAs) were recruited for the study. Pregnancies with fetal anomalies, growth abnormalities, maternal medical complications, stillbirth, birth weight below the 10th or above the 90th percentile, and neonatal anomalies were excluded. The ductus venosus pulsatility index for veins (PIV) and velocity ratios (S/v, S/D, v/D, S/a, v/a, and D/a, where S indicates ventricular systole [s-wave], v, ventricular end-systolic relaxation [v-descent], D, passive diastolic ventricular filling [D-wave], and a, active ventricular filling during atrial systole [a-wave]) were calculated. Separate regression models were fitted to estimate the mean and standard deviation at each GA for each ratio.
A total of 902 velocity wave ratios and ductus venosus PIVs were used for reference ranges. The S/v, S/D, and v/D ratios were not changed with GA (P > .05 for all). The PIV and S/a, v/a, and D/a ratios were reduced with GA (P < .0001 for all). Significant reductions in the means and standard deviations of the PIV and S/a, v/a, and D/a ratios were observed between 17 and 18 weeks' gestation. Therefore, nomograms were separately created between 11 and 17 weeks and 18 and 38 weeks.
We created reference ranges for ductus venosus velocity ratios between 11 and 38 weeks' gestation in normal pregnancies. These reference ranges may prove beneficial for evaluation of fetal conditions that are associated with cardiovascular abnormalities.
本研究旨在建立静脉导管速度比的参考范围。
本研究纳入了 11 至 38 周、确切孕周（GA）的单胎妊娠。排除胎儿畸形、生长异常、母体医学并发症、死胎、出生体重低于第 10 百分位或高于第 90 百分位以及新生儿畸形的妊娠。计算静脉导管搏动指数（PIV）和速度比（S/v、S/D、v/D、S/a、v/a 和 D/a，其中 S 表示心室收缩期[s 波]、v 表示心室收缩末期松弛[v 下降]、D 表示被动舒张期心室充盈[D 波]和 a 表示心房收缩期主动心室充盈[a 波]）。为每个比值拟合单独的回归模型，以估计每个 GA 的平均值和标准差。
共使用了 902 个速度波比值和静脉导管 PIV 来建立参考范围。S/v、S/D 和 v/D 比值与 GA 无关（所有 P >.05）。PIV 和 S/a、v/a 和 D/a 比值随 GA 降低（所有 P <.0001）。在 17 至 18 周妊娠时，PIV 和 S/a、v/a 和 D/a 比值的平均值和标准差均显著降低。因此，在 11 至 17 周和 18 至 38 周之间分别创建了单独的图表。
我们建立了 11 至 38 周正常妊娠静脉导管速度比的参考范围。这些参考范围可能有助于评估与心血管异常相关的胎儿状况。
