Pruksanusak Ninlapa, Kor-anantakul Ounjai, Suntharasaj Thitima, Suwanrath Chitkasaem, Hanprasertpong Tharangrut, Pranpanus Savitree, Geater Alan
Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
Gynecol Obstet Invest. 2014;78(1):22-5. doi: 10.1159/000362273. Epub 2014 May 17.
To establish reference ranges for ductus venosus (DV) blood flow assessment obtained transabdominally at 11-13(+6) weeks of gestation.
A cross-sectional study was conducted on singleton pregnancies with a crown-rump length (CRL) ranging from 45 to 84 mm, normal fetus, and subsequent newborn birth weight appropriate for gestational age. Measurements of DV Doppler variables were performed by experienced sonographers: peak velocity during ventricular systole (S-wave) and diastole (D-wave), nadir during atrial contraction (A-wave), time-averaged maximum velocity (TAmax), pulsatility index for veins (PIV), and peak velocity index for veins (PVIV).
A total of 304 fetuses were included. The mean CRL was 60.7 ± 7.2 mm (range: 45.9-75.5). The mean nuchal translucency measurement was 1.4 ± 0.4 mm. The S-wave, D-wave, A-wave, and TAmax values varied significantly with gestational age (p < 0.05) and regression models were constructed for each variable. The remaining variables, systolic/atrial wave ratio, preload index, PVIV, and PIV, did not vary significantly with gestational age within this CRL range.
Reference ranges for DV Doppler assessment were established in normal fetuses. These ranges may be a useful tool for evaluation of anueploidy and fetal cardiac function.
建立孕11至13⁺⁶周经腹获得的静脉导管（DV）血流评估的参考范围。
对单胎妊娠进行横断面研究，这些妊娠的头臀长（CRL）为45至84毫米，胎儿正常，且随后出生的新生儿体重与孕周相符。由经验丰富的超声检查人员进行DV多普勒变量测量：心室收缩期（S波）和舒张期（D波）的峰值速度、心房收缩期（A波）的最低点、时间平均最大速度（TAmax）、静脉搏动指数（PIV）和静脉峰值速度指数（PVIV）。
共纳入304例胎儿。平均CRL为60.7±7.2毫米（范围：45.9至75.5）。平均颈项透明层测量值为1.4±0.4毫米。S波、D波、A波和TAmax值随孕周有显著变化（p<0.05），并为每个变量构建了回归模型。在该CRL范围内，其余变量，即收缩期/心房波比值、前负荷指数、PVIV和PIV，随孕周无显著变化。
建立了正常胎儿DV多普勒评估的参考范围。这些范围可能是评估非整倍体和胎儿心功能的有用工具。
