缓激肽、组胺和磷脂酸对人角质形成细胞中花生四烯酸分布与释放的干扰。

Interference with the distribution and release of arachidonic acid in human keratinocytes by bradykinin, histamine and phosphatidic acid.

作者信息

Punnonen K, Puustinen T

机构信息

Department of Physiology, University of Turku, Finland.

出版信息

Prostaglandins Leukot Med. 1987 Sep;29(1):19-23. doi: 10.1016/0262-1746(87)90093-x.

DOI:10.1016/0262-1746(87)90093-x

PMID:2444995

Abstract

The effects of bradykinin, histamine, phosphatidic acid and leukotrienes B4 and C4 on the distribution and release of 14C-arachidonic acid in human keratinocytes in culture were investigated. Bradykinin, histamine, and phosphatidic acid were found to liberate 14C-arachidonic acid from membrane phospholipids, whereas leukotrienes B4 and C4 were ineffective in this respect. The decrease in the labeling of phospholipids was accompanied by increased labeling of the non-phosphorus lipids. The present study suggests that bradykinin, histamine, and phosphatidic acid may interfere with the distribution and release of arachidonic acid in human keratinocytes in culture.

摘要

研究了缓激肽、组胺、磷脂酸以及白三烯B4和C4对培养的人角质形成细胞中14C-花生四烯酸分布和释放的影响。发现缓激肽、组胺和磷脂酸可从膜磷脂中释放14C-花生四烯酸，而白三烯B4和C4在这方面无效。磷脂标记的减少伴随着非磷脂脂质标记的增加。本研究表明，缓激肽、组胺和磷脂酸可能会干扰培养的人角质形成细胞中花生四烯酸的分布和释放。