在硅氢加成条件下，叔酰胺的催化还原脱水生成烯胺。
Catalytic reductive dehydration of tertiary amides to enamines under hydrosilylation conditions.
机构信息
Department of Organic Chemistry, Stockholm University , The Arrhenius Laboratory, SE-106 91 Stockholm, Sweden.
出版信息
Org Lett. 2014 Feb 7;16(3):680-3. doi: 10.1021/ol403302g. Epub 2014 Jan 22.
PMID:24451007
Abstract
Tertiary amides are efficiently reduced to their corresponding enamines under hydrosilylation conditions, using a transition-metal-free catalytic protocol based on t-BuOK (5 mol %) and (MeO)3SiH or (EtO)3SiH as the reducing agent. The enamines were formed with high selectivity in good-to-excellent yields.
摘要
叔酰胺在无过渡金属催化条件下，通过硅氢化反应，以 t-BuOK（5mol%）和(MeO)3SiH 或(EtO)3SiH 为还原剂，可高效还原为相应的烯胺。该反应具有高选择性，以较好至优异的收率得到目标产物。
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