短期变应性志愿者实验暴露研究中木烟的全身效应。
Systemic effects of wood smoke in a short-term experimental exposure study of atopic volunteers.
机构信息
From the Section of Environment Work and Health (Drs Bønløkke, Riddervold, and Sigsgaard), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Section of Biostatistics (Ms Grønborg), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Department of Clinical Biochemistry and Immunology (Drs Skogstrand and Hougaard), Statens Serum Institut, Copenhagen, Denmark; and Department of Occupational and Environmental Medicine (Dr Barregard), Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden.
出版信息
J Occup Environ Med. 2014 Feb;56(2):177-83. doi: 10.1097/JOM.0000000000000067.
OBJECTIVE
To investigate whether short-term systemic effects of wood smoke occurred in atopic subjects after experimental wood smoke exposures.
METHODS
A double-blind climate chamber study was conducted on 20 healthy atopic subjects with exposures to filtered air and wood smoke. Pneumoproteins, coagulation and adhesion factors, and cytokines were measured. Heart rate was monitored with pulse monitors. Data were analyzed with mixed models.
RESULTS
Few differences in the outcomes were observed. Plasma tissue factor remained elevated during filtered air exposure (P = 0.002). P-selectin declined independent of exposure (P = 0.0006). Interleukin-6 increased after filtered air (P = 0.03).
CONCLUSIONS
The study confirmed previous observations among nonatopics of limited changes after a 3-hour wood smoke exposure.
目的
研究在实验性木烟暴露后，特应性受试者是否会出现短期的全身系统性影响。
方法
对 20 名健康特应性受试者进行了一项双盲气候室研究，分别暴露于过滤空气和木烟。测量了肺蛋白、凝血和黏附因子以及细胞因子。使用脉搏监测器监测心率。采用混合模型进行数据分析。
结果
观察到的结果差异很小。在过滤空气暴露期间，血浆组织因子持续升高（P = 0.002）。无论暴露与否，P-选择素均下降（P = 0.0006）。白细胞介素-6 在过滤空气后增加（P = 0.03）。
结论
该研究证实了先前在非特应性人群中进行的为期 3 小时的木烟暴露后变化有限的观察结果。
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