Int J Oral Maxillofac Implants. 2014 Jan-Feb;29(1):203-10. doi: 10.11607/jomi.3364.
This study tested the null hypothesis that phosphate-treated titanium implants would perform no differently on mineral apposition rates (MARs), new bone-to-implant contact (new BIC), and total bone-to-implant contact (total BIC) compared to standard titanium implants.
Forty 3.3×8.0-mm titanium implants, either phosphate-treated or untreated, were placed in the mandibles of five foxhounds following 6 weeks of postextraction healing. The untreated implants (control) had sandblasted, acid-etched (SLA) surfaces, while the treated implants were electrolytically phosphorylated at 50 volts (T50) or 100 volts (T100). Confocal and histologic analyses were performed on all the implants after 4 weeks of healing.
The MARs could not be analyzed due to a lack of delineation between the three bone markers. New BIC results for control implants ranged from 6.0% to 56.0% with a mean of 23.92% and standard deviation (SD) of 13.29%; T50 implants ranged from 8.0% to 43.0% with a mean of 22.29% and SD of 10.26%; and T100 implants ranged from 0.0% to 47.0% with a mean of 17.43% and SD of 11.40%. Total BIC results for control implants ranged from 8.0% to 68.0% BIC with a mean of 41.4% and SD of 19.3%; T50 implants ranged from 21.0% to 65.0% with a mean of 43.7% and SD of 15.2%; and T100 implants ranged from 5.0% to 68.0% with a mean of 38.0% and SD of 19.5%.
Within the limitations of this pilot study, no significant differences in new BIC or total BIC were found between the three implant groups (C, T50, and T100). Given the very large sample size required to show clinically significant differences, phosphated surfaces do not appear to provide additional advantages to SLA surfaces.
本研究旨在检验一个零假设，即经过磷酸盐处理的钛种植体在矿化附着率（MAR）、新骨-种植体接触率（new BIC）和总骨-种植体接触率（total BIC）方面与标准钛种植体无显著差异。
40 枚 3.3×8.0mm 的钛种植体，分别经过磷酸盐处理或未处理，在 5 只猎狐犬拔牙后 6 周的愈合期后植入下颌骨。未经处理的种植体（对照组）具有喷砂酸蚀（SLA）表面，而经处理的种植体则在 50 伏（T50）或 100 伏（T100）下进行电解磷酸化。所有种植体在愈合 4 周后进行共聚焦和组织学分析。
由于三种骨标记物之间无法区分，MAR 无法进行分析。对照组种植体的新 BIC 结果范围为 6.0%至 56.0%，平均值为 23.92%，标准差（SD）为 13.29%；T50 种植体的范围为 8.0%至 43.0%，平均值为 22.29%，SD 为 10.26%；T100 种植体的范围为 0.0%至 47.0%，平均值为 17.43%，SD 为 11.40%。对照组种植体的总 BIC 结果范围为 8.0%至 68.0%的 BIC，平均值为 41.4%，SD 为 19.3%；T50 种植体的范围为 21.0%至 65.0%，平均值为 43.7%，SD 为 15.2%；T100 种植体的范围为 5.0%至 68.0%，平均值为 38.0%，SD 为 19.5%。
在本初步研究的限制内，三组种植体（C、T50 和 T100）之间的新 BIC 或总 BIC 无显著差异。鉴于要显示出具有临床意义的差异所需的非常大的样本量，磷酸化表面似乎并未为 SLA 表面提供额外的优势。
