Bornstein Michael M, Valderrama Pilar, Jones Archie A, Wilson Thomas G, Seibl Reinhart, Cochran David L
Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Clin Oral Implants Res. 2008 Mar;19(3):233-41. doi: 10.1111/j.1600-0501.2007.01473.x. Epub 2008 Jan 3.
The aim of this study was to evaluate bone apposition to a modified sandblasted and acid-etched (SLA) implant surface (modSLA) in the canine mandible as compared with the standard SLA surface.
In this experimental study, all mandibular premolars and first molars were extracted bilaterally in five foxhounds. After a healing period of 6 months, each side of the mandible received six randomly assigned dental implants alternating between the standard SLA and modSLA surface. The dogs were sacrificed at 2 weeks (n=2) or 4 weeks (n=3) after implant placement. Histologic and histomorphometric analyses were then performed for each implant.
The microscopic healing patterns at weeks 2 and 4 for the two implant types with the standard SLA and modSLA surfaces showed similar qualitative findings. New bone tissue had already established direct contact with implant surfaces after 2 weeks of healing. The mean percentage of newly formed bone in contact with the implant (BIC) was significantly greater for modSLA (28.2+/-7.9%) than for SLA (22.2+/-7.3%) (P<0.05). This difference was no longer evident after 4 weeks. An increase in BIC for both implant surface types occurred from weeks 2 to 4. This increase was statistically significant when compared with SLA at 2 weeks (P<0.05), but not when compared with modSLA at 2 weeks.
The data from the present study demonstrate significantly more bone apposition for the modSLA surface than the standard SLA surface after 2 weeks of healing. This increased bone apposition may allow a further reduction of the healing period following implant placement for patients undergoing early loading procedures.
本研究旨在评估与标准喷砂酸蚀（SLA）种植体表面相比，改良喷砂酸蚀（modSLA）种植体表面在犬下颌骨中的骨结合情况。
在本实验研究中，对5只猎狐犬双侧拔除所有下颌前磨牙和第一磨牙。经过6个月的愈合期后，下颌骨的每一侧随机植入6颗种植体，标准SLA表面和modSLA表面交替使用。种植体植入后2周（n = 2）或4周（n = 3）处死实验犬。然后对每个种植体进行组织学和组织形态计量学分析。
标准SLA表面和modSLA表面的两种种植体在第2周和第4周的微观愈合模式显示出相似的定性结果。愈合2周后，新骨组织已与种植体表面直接接触。modSLA组与种植体接触的新形成骨的平均百分比（骨结合率，BIC）显著高于SLA组（28.2±7.9% 比 22.2±7.3%）（P<0.05）。4周后这种差异不再明显。两种种植体表面类型的BIC从第2周到第4周均有所增加。与2周时的SLA组相比，这种增加具有统计学意义（P<0.05），但与2周时的modSLA组相比则无统计学意义。
本研究数据表明，愈合2周后，modSLA表面的骨结合明显多于标准SLA表面。这种增加的骨结合可能允许进一步缩短接受早期负载程序患者种植体植入后的愈合期。
