Brumfield C G, Cloud G A, Finley S C, Cosper P, Davis R O, Huddleston J F
Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35294.
Am J Obstet Gynecol. 1987 Oct;157(4 Pt 1):822-5. doi: 10.1016/s0002-9378(87)80063-7.
Elevated and low levels of maternal serum alpha-fetoprotein in the midtrimester of pregnancy have been linked with adverse events in later gestation, such as fetal and neonatal deaths, chromosomal abnormalities, and low birth weight infants. It is not known if this same association with poor pregnancy outcome is also true of amniotic fluid alpha-fetoprotein. In this study, alpha-fetoprotein was obtained from the fluid of 1060 women undergoing genetic amniocentesis for advanced maternal age. Poor pregnancy outcome was defined as (1) a fetal or neonatal death, (2) preterm delivery, or (3) low birth weight infants. Amniotic fluid alpha-fetoprotein was compared to each type of adverse outcome. No significant association with a poor pregnancy outcome in later gestation was noted. Although serum alpha-fetoprotein in the midtrimester of pregnancy may relate to certain poor outcomes in later gestation, midtrimester amniotic fluid alpha-fetoprotein offers no predictive value for the course of events in later gestation.
妊娠中期孕妇血清甲胎蛋白水平的升高和降低与后期妊娠的不良事件有关，如胎儿和新生儿死亡、染色体异常以及低体重儿。目前尚不清楚羊水甲胎蛋白与不良妊娠结局之间是否也存在同样的关联。在本研究中，从1060名因母亲年龄较大而接受遗传羊膜穿刺术的女性的羊水中获取了甲胎蛋白。不良妊娠结局定义为：（1）胎儿或新生儿死亡；（2）早产；或（3）低体重儿。将羊水甲胎蛋白与每种不良结局进行了比较。未发现与后期妊娠不良结局有显著关联。尽管妊娠中期的血清甲胎蛋白可能与后期妊娠的某些不良结局有关，但妊娠中期的羊水甲胎蛋白对后期妊娠的病程没有预测价值。
