Verspyck E, Degré S, Hellot M F, Descargues G, Philippe C, Labadie G, Bénichou J, Lemoine J P, Marpeau L
Department of Obstetrics and Gynaecology, Rouen University Hospital, Rouen, France.
Prenat Diagn. 1999 Nov;19(11):1031-4. doi: 10.1002/(sici)1097-0223(199911)19:11<1031::aid-pd684>3.0.co;2-7.
The aim of our study was to determine if the amniotic fluid alpha-fetoprotein (AFP) level could be a useful predictive biochemical marker of pregnancy outcome. Amniotic fluid AFP measurement was prospectively carried out over a three-year period. After excluding factors susceptible to modifying AFP measurements, 587 subjects with gestational age between 14 and 20 weeks were selected to compare the amniotic fluid AFP mean levels depending on the occurrence of an adverse outcome. No significant associations between amniotic fluid AFP level and poor pregnancy outcome, i.e. pre-eclampsia, preterm delivery, premature rupture of fetal membranes, fetal growth retardation and placental abnormalities were observed. The routine measurement of amniotic fluid alpha-fetoprotein during an amniocentesis procedure was not considered useful in predicting pregnancy complications.
我们研究的目的是确定羊水甲胎蛋白（AFP）水平是否可作为预测妊娠结局的有用生化标志物。在三年期间前瞻性地进行了羊水AFP测量。在排除易影响AFP测量的因素后，选择了587名孕周在14至20周之间的受试者，根据不良结局的发生情况比较羊水AFP平均水平。未观察到羊水AFP水平与不良妊娠结局（即子痫前期、早产、胎膜早破、胎儿生长受限和胎盘异常）之间存在显著关联。在羊膜穿刺术过程中常规测量羊水甲胎蛋白对预测妊娠并发症并无用处。
