Werquin S, Kacet S, Caron J, Lacroix D, Libersa C, Coget J M, Lekieffre J
Service de Cardiologie A., Hôpital Cardiologique, Lille.
Ann Cardiol Angeiol (Paris). 1987 Oct;36(8):409-12.
Bleomycin is sometimes at the origin of a Raynaud's phenomenon (RP). From the literature, there does not seem to exist a dose-dependent relationship. The phenomenon occurs early or late and often is resistant to various medications. The possible physiopathological mechanisms are: direct vascular toxicity, hypersensitivity vascularization, alteration of platelets activity, alteration of Willebrand's factor, and as predisposing factors: association to periwinkle alkaloids or hypomagnesemia.
博来霉素有时会引发雷诺现象（RP）。从文献来看，似乎不存在剂量依赖关系。该现象可早发或晚发，且常常对各种药物耐药。可能的生理病理机制为：直接血管毒性、血管超敏反应、血小板活性改变、血管性血友病因子改变，以及作为易感因素的长春花生物碱联合使用或低镁血症。
