Gupta Seema, Pant Mohan Chand, Husain Nuzhat, Sundar Sham, Khan Huma
Department of Radiotherapy, C.S.M. Medical University, Chowk St., Lucknow 226003, India. Seemagupta02sify.com.
Ear Nose Throat J. 2014 Jan;93(1):E12-4.
Primary mucosal malignant melanomas of the nose are rare, accounting for only 0.3 to 2% of all cases of malignant melanoma and about 4% of all head and neck melanomas. The amelanotic variant of mucosal malignant melanoma is even more rare, and the prognosis is poor. This variant usually arises in locations in which it is not noticeable, and therefore it is usually diagnosed at an advanced clinical stage when symptoms eventually manifest. We report a case of locally advanced amelanotic melanoma of the nasal cavity in a 55-year-old woman who presented with complaints of nasal obstruction and intermittent bleeding on the right side of the nose for 3 months and a gradually progressive diffuse swelling over the right periorbital and maxillary areas for 2 months with associated pain for 15 days. She was diagnosed with amelanotic melanoma on the basis of clinical, radiologic, and pathologic findings. In view of her advanced disease, she declined surgery and was treated with chemoradiotherapy, and she experienced a significant alleviation of her symptoms.
鼻腔原发性黏膜恶性黑色素瘤较为罕见，仅占所有恶性黑色素瘤病例的0.3%至2%，约占所有头颈部黑色素瘤的4%。黏膜恶性黑色素瘤的无色素变异型更为罕见，预后较差。这种变异型通常发生在不易被察觉的部位，因此通常在症状最终出现时的晚期临床阶段才被诊断出来。我们报告一例55岁女性鼻腔局部晚期无色素黑色素瘤病例，该患者主诉右侧鼻塞和鼻出血3个月，右侧眶周和上颌区域逐渐进行性弥漫性肿胀2个月，并伴有疼痛15天。根据临床、影像学和病理检查结果诊断为无色素黑色素瘤。鉴于其疾病已处于晚期，她拒绝手术，接受了放化疗，症状得到明显缓解。
