基于核壳纳米粒子的比率磁共振成像传感器用于定量 pH 成像。
Ratiometric MRI sensors based on core-shell nanoparticles for quantitative pH imaging.
机构信息
Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
出版信息
Adv Mater. 2014 May 21;26(19):2989-92. doi: 10.1002/adma.201305018. Epub 2014 Jan 22.
PMID:24453039
Abstract
Ratiometric MRI sensors consist of paramagnetic cores and pH-sensitive polymer shells. The core-shell nanostructure enables the coexistence of two incompatible NMR relaxation properties in one particle. The sensors show pH sensitivity in transverse relaxivity (r2 ), but not in longitudinal relaxivity (r1 ). Quantitative pH imaging is achieved by measuring the r2 /r1 value with a clinical 3 T MRI scanner.
摘要
比率磁共振成像（rMRI）传感器由顺磁核和 pH 敏感聚合物壳组成。核壳纳米结构使两种不相容的 NMR 弛豫性能在一个颗粒中共存。该传感器在横向弛豫率（r2）方面表现出 pH 敏感性，但在纵向弛豫率（r1）方面没有。通过使用临床 3 T MRI 扫描仪测量 r2/r1 值，实现定量 pH 成像。
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