Chemistry Department, East China Normal University, Shanghai 200241, PR China; Antibiotics Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, PR China.
Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, PR China.
Talanta. 2015 Jan;131:661-5. doi: 10.1016/j.talanta.2014.08.042. Epub 2014 Aug 26.
Core/shell/shell structured Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)2 and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd(3+) enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd(3+) and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications.
核壳/壳结构 Fe3O4/SiO2/Gd2O(CO3)2 纳米粒子成功合成。研究了它们作为磁共振成像新型 T1-T2 双模式对比剂的性质。由于引入了分离的 SiO2 层，SiO2 层的厚度可以调节 Gd2O(CO3)2 和 Fe3O4 之间的磁耦合，从而产生适当的 T1 和 T2 信号。此外，Gd(3+)的存在增强了 Fe3O4 的横向弛豫率，可能是因为 Gd(3+)和 Fe3O4 之间的磁耦合。Fe3O4/SiO2/Gd2O(CO3)2 纳米粒子具有良好的生物相容性，在生物医学应用方面具有很大的潜力。
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