Department of Sport Science, University of Innsbruck, Fürstenweg 185 , Innsbruck, Austria.
J Sports Sci Med. 2005 Sep 1;4(3):314-22.
L-arginine-L-aspartate is widely used by athletes for its potentially ergogenic properties. However, only little information on its real efficacy is available from controlled studies. Therefore, we evaluated the effects of prolonged supplementation with L-arginine-L-aspartate on metabolic and cardiorespiratory responses to submaximal exercise in healthy athletes by a double blind placebo-controlled trial. Sixteen healthy male volunteers (22 ± 3 years) performed incremental cycle spiroergometry up to 150 watts before and after intake of L-arginine-L-aspartate (3 grams per day) or placebo for a period of 3 weeks. After intake of L-arginine-L-aspartate, blood lactate at 150 watts dropped from 2.8 ± 0.8 to 2.0 ± 0.9 mmol·l(-1) (p < 0.001) and total oxygen consumption during the 3-min period at 150 watts from 6.32 ± 0.51 to 5.95 ± 0.40 l (p = 0.04) compared to placebo (2.7 ± 1.1 to 2.7 ± 1.4 mmol·l(-1); p = 0.9 and 6.07 ± 0.51 to 5.91 ± 0.50 l; p = 0.3). Additionally, L-arginine-L-aspartate supplementation effected an increased fat utilisation at 50 watts. L-arginine and L-aspartate seem to have induced synergistic metabolic effects. L-arginine might have reduced lactic acid production by the inhibition of glycolysis and L-aspartate may have favoured fatty acid oxidation. Besides, the results indicate improved work efficiency after L-arginine-L-aspartate intake. The resulting increases of submaximal work capacity and exercise tolerance may have important implications for athletes as well as patients. Key PointsAmino acids are among the most common nutritional supplements taken by athletes. They are involved in numerous metabolic pathways that affect exercise metabolism.Three weeks of L-arginine-L-aspartate supplementation resulted in lower blood lactate concentrations and oxygen consumption, diminished glucose and enhanced fat oxidation, and reduced heart rate and ventilation during submaximal cycle exercise.This implies increased submaximal work capacity and exercise tolerance, which may have important implications for both athletes as well as patients.
左旋精氨酸-天门冬氨酸因其潜在的运动能力而被运动员广泛使用。然而，只有很少的受控研究提供了关于其真正疗效的信息。因此，我们通过双盲安慰剂对照试验评估了长期补充左旋精氨酸-天门冬氨酸对健康运动员亚最大运动代谢和心肺反应的影响。16 名健康男性志愿者（22 ± 3 岁）在摄入左旋精氨酸-天门冬氨酸（每天 3 克）或安慰剂之前和之后进行递增式自行车测功计运动，直至达到 150 瓦。摄入左旋精氨酸-天门冬氨酸后，150 瓦时的血乳酸从 2.8 ± 0.8 降至 2.0 ± 0.9 mmol·l(-1)（p < 0.001），150 瓦时 3 分钟期间的总耗氧量从 6.32 ± 0.51 降至 5.95 ± 0.40 l（p = 0.04）与安慰剂相比（2.7 ± 1.1 至 2.7 ± 1.4 mmol·l(-1)；p = 0.9 和 6.07 ± 0.51 至 5.91 ± 0.50 l；p = 0.3）。此外，左旋精氨酸-天门冬氨酸补充剂可增加 50 瓦时的脂肪利用率。左旋精氨酸和天门冬氨酸似乎产生了协同代谢作用。左旋精氨酸可能通过抑制糖酵解来减少乳酸的产生，而天门冬氨酸可能有利于脂肪酸的氧化。此外，结果表明，摄入左旋精氨酸-天门冬氨酸后工作效率提高。亚最大运动能力和运动耐力的增加可能对运动员和患者都有重要意义。关键点氨基酸是运动员最常服用的营养补充剂之一。它们参与了许多影响运动代谢的代谢途径。左旋精氨酸-天门冬氨酸补充剂持续 3 周可降低血乳酸浓度和耗氧量，减少葡萄糖和增强脂肪氧化，并降低亚最大循环运动时的心率和通气量。这意味着亚最大运动能力和运动耐力增加，这可能对运动员和患者都有重要意义。
