3-O-α-L-鼠李糖基-（4-O-α-D-葡萄糖基）-α-D-半乳糖吡喃糖和3-O-α-L-鼠李糖基-（4-O-β-D-葡萄糖基）-α-D-半乳糖吡喃糖的莫拉戊烯基焦磷酸衍生物的合成及其在鼠伤寒沙门氏菌和鸭沙门氏菌O抗原多糖生物合成反应中底物性质的研究
[Synthesis of moraprenylpyrophosphate derivatives of 3-O-alpha-L-rhamnopyranosyl-(4-O-alpha-D-glucopyranosyl)-alpha-D- galactopyranose and 3-O-alpha-L-rhamnopyranosyl-(4-O-beta-D- glucopyranosyl)-alpha-D-galactopyranose and study of their substrate properties in reactions of the biosynthesis of O-antigenic polysaccharides of Salmonella typhimurium and Salmonella anatum].
作者信息
Torgov V I, Druzhinina T N, Nechaev O A, Shibaev V N
出版信息
Bioorg Khim. 1987 Jul;13(7):947-57.
Trisaccharides Rha alpha 1----3(Glc alpha 1----4)Gal (I) and Rha alpha 1----3(Glc beta 1----4) Gal (II) have been synthesised. Acetylation of the trisaccharides followed by the McDonald reaction gave rise to alpha-glycosyl phosphates. The latter were converted via coupling with moraprenyl phosphoimidazolidate into polyprenyl pyrophosphate derivatives of (I) and (II), which both serve as substrates for mannosylation and polymerisation reactions with enzymes form the Salmonella anatum and S. typhimurium membranes.
已合成三糖鼠李糖α1----3（葡萄糖α1----4）半乳糖（I）和鼠李糖α1----3（葡萄糖β1----4）半乳糖（II）。三糖乙酰化后进行麦克唐纳反应生成α-糖基磷酸酯。后者通过与莫拉戊烯基磷酰咪唑化物偶联转化为（I）和（II）的聚戊烯基焦磷酸衍生物，这两种衍生物均作为来自肠炎沙门氏菌和鼠伤寒沙门氏菌膜的酶进行甘露糖基化和聚合反应的底物。
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