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固定后进行运动的成年和老年大鼠的肌肉力学特性

Muscle mechanical properties of adult and older rats submitted to exercise after immobilization.

作者信息

Kodama Fábio Yoshikazu, Camargo Regina Celi Trindade, Job Aldo Eloizo, Ozaki Guilherme Akio Tamura, Koike Tatiana Emy, Camargo Filho José Carlos Silva

机构信息

Faculdade de Ciências e Tecnologia - FCT/UNESP - Presidente Prudente, SP, Brazil.

出版信息

Acta Ortop Bras. 2012;20(4):218-22. doi: 10.1590/S1413-78522012000400005.

DOI:10.1590/S1413-78522012000400005
PMID:24453606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3718404/
Abstract

OBJECTIVES

To describe the effects of immobilization, free remobilization and remobilization by physical exercise about mechanical properties of skeletal muscle of rats of two age groups.

METHODS

56 Wistar rats divided into two groups according to age, an adult group (five months) and an older group (15 months). These groups were subdivided in: control, immobilized, free remobilized and remobilized by physical exercise. The pelvic limb of rats was immobilized for seven days. The exercise protocol consisted of five swimming sessions, once per day and 25 minutes per session. The gastrocnemius muscle was subjected to tensile tests, and evaluated the properties: load at the maximum limit, stretching at the maximum limit and stiffness.

RESULTS

The immobilization reduced the values of load at the maximum limit and the remobilization protocols were not sufficient to restore control levels in adult group and older rats. The stretching at the maximum limit differs only in the older group.

CONCLUSIONS

The immobilization reduces the muscle's ability to bear loads and exercise protocol tends to restore the default at control values in adult and older rats. The age factor only interfered in the stretching at the maximum limit, inducing a reduction of this property in the post-immobilization. Level of Evidence II, Investigating the Results of Treatment.

摘要

目的

描述制动、自由活动恢复和体育锻炼恢复对两个年龄组大鼠骨骼肌力学性能的影响。

方法

56只Wistar大鼠按年龄分为两组,成年组(5个月)和老年组(15个月)。这些组再细分为:对照组、制动组、自由活动恢复组和体育锻炼恢复组。将大鼠的后肢制动7天。运动方案包括5次游泳训练,每天1次,每次25分钟。对腓肠肌进行拉伸试验,并评估其性能:最大极限负荷、最大极限拉伸和刚度。

结果

制动降低了最大极限负荷值,恢复方案不足以使成年组和老年大鼠恢复到对照水平。最大极限拉伸仅在老年组有所不同。

结论

制动会降低肌肉承受负荷的能力,运动方案倾向于使成年和老年大鼠恢复到对照值的默认状态。年龄因素仅影响最大极限拉伸,导致制动后该性能降低。证据水平II,治疗结果研究。

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本文引用的文献

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Exercise training modulates the nitric oxide synthase profile in skeletal muscle from old rats.运动训练可调节老年大鼠骨骼肌中的一氧化氮合酶谱。
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Biomechanical effects of immobilization and rehabilitation on the skeletal muscle of trained and sedentary rats.
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Age-induced morphological, biochemical, and functional alterations in isolated mitochondria from murine skeletal muscle.衰老诱导的小鼠骨骼肌分离线粒体的形态、生化及功能改变。
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