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Taxol counteracts colchicine blockade of axonal transport in neurites of cultured dorsal root ganglion cells.

作者信息

Horie H, Takenaka T, Ito S, Kim S U

机构信息

Department of Physiology, Yokohama City University, School of Medicine, Japan.

出版信息

Brain Res. 1987 Sep 8;420(1):144-6. doi: 10.1016/0006-8993(87)90249-6.

DOI:10.1016/0006-8993(87)90249-6
PMID:2445429
Abstract

Taxol does not affect axonal transport in cultured neurites. Preincubation of this drug inhibits the effects of colchicine on axonal transport and morphology in cultured neurites. A reduction of the free tubulin density by preincubated taxol might prevent the disruption of microtubules by colchicine.

摘要

相似文献

1
Taxol counteracts colchicine blockade of axonal transport in neurites of cultured dorsal root ganglion cells.
Brain Res. 1987 Sep 8;420(1):144-6. doi: 10.1016/0006-8993(87)90249-6.
2
Effects of disruption of microtubules on translocation of particles and morphology in tissue cultured neurites.微管破坏对组织培养神经突中颗粒转运及形态的影响。
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Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglia neurons in vitro.紫杉醇在体外损害背根神经节神经元中微量注射的辣根过氧化物酶的顺行轴突运输。
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Preferential blockade of the tubulin transport by colchicine.秋水仙碱对微管蛋白转运的优先阻断作用。
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Inhibitory effect of histamine on axonal transport in cultured mouse dorsal root ganglion neurons.组胺对培养的小鼠背根神经节神经元轴突运输的抑制作用。
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Dissociation of the inhibition of fast axonal transport by chlorimipramine from an effect on axonal microtubules.
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A correlation between the effects of anti-mitotic drugs on microtubule assembly in vitro and the inhibition of axonal transport in noradrenergic neurones.抗有丝分裂药物在体外对微管装配的影响与去甲肾上腺素能神经元轴突运输抑制之间的相关性。
J Physiol. 1975 Oct;252(1):283-94. doi: 10.1113/jphysiol.1975.sp011144.
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Morphological alterations in dorsal root ganglion neurons and supporting cells of organotypic mouse spinal cord-ganglion cultures exposed to taxol.暴露于紫杉醇的器官型小鼠脊髓神经节培养物中背根神经节神经元和支持细胞的形态学改变。
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Extracellular potassium rapidly inhibits axonal transport of particles in cultured mouse dorsal root ganglion neurites.细胞外钾离子可迅速抑制培养的小鼠背根神经节神经突中颗粒的轴突运输。
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Neurosci Lett. 2013 May 24;543:101-4. doi: 10.1016/j.neulet.2013.03.051. Epub 2013 Apr 9.

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