Nagashima A, Takano Y, Tateishi K, Matsuoka Y, Hamaoka T, Kamiya H
Department of Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Japan.
Brain Res. 1989 May 22;487(2):392-6. doi: 10.1016/0006-8993(89)90848-2.
Unilateral removal of the afferent fibers of the IXth and Xth cranial nerve (nodose ganglionectomy) caused significant decrease in the content of substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) in the nucleus tractus solitarii (NTS) of rats. Microinjection of SP (1 ng) or NKA (10-100 ng) into the NTS caused prompt, transient hypotension and bradycardia, suggesting that SP and NKA may be neurotransmitters of the baroreceptor reflex in the NTS. NKB-like immunoreactivity (NKB-LI) was also detected in the NTS of rats by radioimmunoassay, but its content in the NTS was not affected by unilateral nodose ganglionectomy. The microinjection of 1-10 ng of suc-[Asp5, Me-Phe8]-SP(6-11) (senktide, a selective neurokinin B receptor peptide) into the NTS caused long-lasting hypertension and tachycardia. These results indicate that NKB may also be a neuromodulator on cardiovascular responses in the NTS.
单侧切除第九和第十对脑神经的传入纤维（结状神经节切除术）导致大鼠孤束核（NTS）中P物质样免疫反应性（SP-LI）和神经激肽A样免疫反应性（NKA-LI）的含量显著降低。向NTS微量注射SP（1纳克）或NKA（10 - 100纳克）会引起迅速、短暂的低血压和心动过缓，这表明SP和NKA可能是NTS中压力感受器反射的神经递质。通过放射免疫测定法在大鼠的NTS中也检测到了神经激肽B样免疫反应性（NKB-LI），但其在NTS中的含量不受单侧结状神经节切除术的影响。向NTS微量注射1 - 10纳克的suc - [Asp5, Me - Phe8] - SP(6 - 11)（senktide，一种选择性神经激肽B受体肽）会引起持久的高血压和心动过速。这些结果表明，NKB也可能是NTS中对心血管反应的一种神经调节剂。
