从 Baylis-Hillman 加成物出发的 (+)-grandiamide D、dasyclamide 和 gigantamide A 的全合成：一种统一的仿生方法。
Total synthesis of (+)-grandiamide D, dasyclamide and gigantamide A from a Baylis-Hillman adduct: A unified biomimetic approach.
机构信息
School of Chemistry, Bharathidasan University, Tiruchirappalli, 620024, India.
School of Chemistry, Bharathidasan University, Tiruchirappalli, 620024, India ; Syngene International Ltd., Bangalore, 560 099, India.
出版信息
Beilstein J Org Chem. 2014 Jan 10;10:127-33. doi: 10.3762/bjoc.10.9.
A unified strategy was followed for the synthesis of three putrescine bisamides, (+)-grandiamide D, dasyclamide and gigantamide A, isolated from leaves of Aglaia gigantea, by making use of a common synthetic intermediate prepared by the Baylis-Hillman reaction. Asymmetric synthesis of the natural (+)-grandiamide D was accomplished from camphor sultam.
采用统一的策略，通过利用 Baylis-Hillman 反应制备的共同合成中间体，从 Aglaia gigantea 的叶子中分离得到的腐胺双酰胺 (+)-grandiamide D、dasyclamide 和 gigantamide A 进行了三种化合物的合成。通过莰烷砜实现了天然 (+)-grandiamide D 的不对称合成。
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