环状胺、2-氨基苯并噻唑、芳香醛和丙二炔二羧酸的四组分反应。
Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate.
机构信息
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
出版信息
Beilstein J Org Chem. 2013 Dec 27;9:2934-9. doi: 10.3762/bjoc.9.330.
Abstract
The four-component reaction of 2-aminobenzothiazole, aromatic aldehydes, acetylenedicarboxylate and piperidine or pyrrolidine in ethanol afforded the functionalized 2-pyrrolidinones containing both benzothiazolyl and piperidinyl (or pyrrolidinyl) units in good yields. On the other hand, the similar four-component reactions resulted in the functionalized morpholinium or piperidinium 2-pyrrolidinon-3-olates in the presence of p-toluenesulfonic acid.
摘要
2-氨基苯并噻唑、芳香醛、乙酰基二羧酸酯和哌啶或吡咯烷在乙醇中的四组分反应以良好的收率提供了既含苯并噻唑基又含哌啶基（或吡咯烷基）单元的功能化 2-吡咯烷酮。另一方面，在对甲苯磺酸存在下，类似的四组分反应导致功能化的吗啉鎓或哌啶鎓 2-吡咯烷酮-3-醇盐生成。
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