Boddaert Jacques, Cohen-Bittan Judith, Khiami Frédéric, Le Manach Yannick, Raux Mathieu, Beinis Jean-Yves, Verny Marc, Riou Bruno
Université Pierre et Marie Curie (UMRS 956, UMRS 1158), Paris, France ; Department of Geriatrics, Groupe hospitalier (GH) Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris (APHP), Paris, France.
Université Pierre et Marie Curie (UMRS 956, UMRS 1158), Paris, France.
PLoS One. 2014 Jan 15;9(1):e83795. doi: 10.1371/journal.pone.0083795. eCollection 2014.
Elderly patients with hip fracture have a 5 to 8 fold increased risk of death during the months following surgery. We tested the hypothesis that early geriatric management of these patients focused on co-morbidities and rehabilitation improved long term mortality.
In a cohort study over a 6 year period, we compared patients aged >70 years with hip fracture admitted to orthopedic versus geriatric departments in a time series analysis corresponding to the creation of a dedicated geriatric unit. Co-morbidities were assessed using the Cumulative Illness Rating Scale (CIRS). Each cohort was compared to matched cohorts extracted from a national registry (n = 51,275) to validate the observed results. Main outcome measure was 6-month mortality. We included 131 patients in the orthopedic cohort and 203 in the geriatric cohort. Co-morbidities were more frequent in the geriatric cohort (median CIRS: 8 vs 5, P<0.001). In the geriatric cohort, the proportion of patients who never walked again decreased (6% versus 22%, P<0.001). At 6 months, re-admission (14% versus 29%, P = 0.007) and mortality (15% versus 24%, P = 0.04) were decreased. When co-morbidities were taken into account, the risk ratio of death at 6 months was reduced (0.43, 95%CI 0.25 to 0.73, P = 0.002). Using matched cohorts, the average treatment effects on the treated associated to early geriatric management indicated a reduction in hospital mortality (-63%; 95% CI: -92% to -6%, P = 0.006).
Early admission to a dedicated geriatric unit improved 6-month mortality and morbidity in elderly patients with hip fracture.
老年髋部骨折患者在术后数月内死亡风险增加5至8倍。我们检验了这样一个假设,即针对这些患者的早期老年病管理,聚焦于合并症和康复,可改善长期死亡率。
在一项为期6年的队列研究中,我们在对应设立专门老年病科的时间序列分析中,比较了年龄>70岁的髋部骨折患者入住骨科与老年病科的情况。使用累积疾病评定量表(CIRS)评估合并症。将每个队列与从国家登记处提取的匹配队列(n = 51,275)进行比较,以验证观察结果。主要结局指标是6个月死亡率。我们纳入了131例骨科队列患者和203例老年病科队列患者。老年病科队列中的合并症更为常见(CIRS中位数:8比5,P<0.001)。在老年病科队列中,再也无法行走的患者比例下降(6%对22%,P<0.001)。在6个月时,再次入院率(14%对29%,P = 0.007)和死亡率(15%对24%,P = 0.04)均下降。考虑合并症时,6个月时的死亡风险比降低(0.43,95%CI 0.25至0.73,P = 0.002)。使用匹配队列,早期老年病管理对治疗对象的平均治疗效果表明医院死亡率降低(-63%;95%CI:-92%至-6%,P = 0.006)。
早期入住专门的老年病科可改善老年髋部骨折患者的6个月死亡率和发病率。