氟化物水平与骨肉瘤
Fluoride levels and osteosarcoma.
作者信息
Kharb Simmi, Sandhu Ravindra, Kundu Zile Singh
机构信息
Department of Biochemistry, Pt.BDS PGIMS, Rohtak, India.
Department of Orthopedics, Pt.BDS PGIMS, Rohtak, India.
出版信息
South Asian J Cancer. 2012 Oct;1(2):76-7. doi: 10.4103/2278-330X.103717.
CONTEXT
Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma.
AIMS
The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water.
SETTINGS AND DESIGN
The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls).
MATERIALS AND METHODS
Serum and drinking water fluoride levels were estimated by ion selective electrode.
STATISTICAL ANALYSIS USED
The data were computed as mean ± SD and Student's t test was applied.
RESULTS
Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P > 0.05, P > 0.001, respectively).
CONCLUSIONS
These results suggest a link between fluoride exposure and osteosarcoma.
背景
骨肉瘤是一种罕见的恶性骨肿瘤，常见于10至24岁的年龄组。最近的报告表明，氟暴露与骨肉瘤之间存在联系。
目的
本研究旨在分析骨肉瘤患者的血清氟水平及其饮用水中的氟含量。
设置与设计
本研究通过比较10例骨肉瘤患者和10名健康志愿者（作为对照）进行。
材料与方法
采用离子选择电极法测定血清和饮用水中的氟水平。
所用统计分析方法
数据以平均值±标准差计算，并应用学生t检验。
结果
与对照组相比，骨肉瘤患者的血清和饮用水氟水平均显著较高（分别为P>0.05，P>0.001）。
结论
这些结果表明氟暴露与骨肉瘤之间存在联系。
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