Operskalski E A, Preston-Martin S, Henderson B E, Visscher B R
Am J Epidemiol. 1987 Jul;126(1):118-26. doi: 10.1093/oxfordjournals.aje.a114643.
A study of 64 cases and 124 friend and neighbor controls was conducted to identify factors associated with the occurrence of osteosarcoma in young persons. Two types of information were collected: questionnaire data from telephone interviews with mothers, and data on height since birth from family, physician, and school records. Cases were not taller at the time of diagnosis than controls, nor were growth rates higher--either overall or during the 3-4 years prior to diagnosis. An excess risk, however, was observed among subjects whose birth length was at or below the 25th percentile, based on national standards. An excess risk was also found among subjects born more than one week early, but the positive association with short birth length remained when duration of pregnancy was taken into account. Positive associations were also found for prior trauma to the tumor site; congenital skeletal defects or other treated bone conditions; fetal x-ray; and maternal employment during pregnancy in manufacturing industries.
一项针对64例骨肉瘤患者及124名作为对照的朋友和邻居展开的研究，旨在确定与年轻人骨肉瘤发病相关的因素。收集了两类信息：通过与母亲进行电话访谈获取的问卷数据，以及来自家庭、医生和学校记录的自出生以来的身高数据。病例在诊断时并不比对照组高，其生长速率也没有更高——无论是总体生长速率，还是在诊断前的3至4年期间。然而，根据国家标准，出生时身长处于或低于第25百分位数的受试者存在额外风险。早产超过一周的受试者中也发现了额外风险，但在考虑妊娠期后，与出生时身长较短的正相关关系依然存在。在肿瘤部位既往有创伤、先天性骨骼缺陷或其他已治疗的骨骼疾病、胎儿接受过x光照射以及母亲孕期在制造业工作的受试者中也发现了正相关关系。
