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非侵入性结直肠癌筛查潜在创新的偏好:一项针对荷兰筛查活动的标记离散选择实验

Preferences for potential innovations in non-invasive colorectal cancer screening: A labeled discrete choice experiment for a Dutch screening campaign.

作者信息

Benning Tim M, Dellaert Benedict G C, Dirksen Carmen D, Severens Johan L

机构信息

Institute of Health Policy & Management, Institute for Medical Technology Assessment, Erasmus University Rotterdam , Rotterdam , The Netherlands.

出版信息

Acta Oncol. 2014 Jul;53(7):898-908. doi: 10.3109/0284186X.2013.877159. Epub 2014 Jan 23.

DOI:10.3109/0284186X.2013.877159
PMID:24456499
Abstract

BACKGROUND

The introduction of innovative non-invasive screening tests (e.g. tests based on stool and blood samples or both) may be a solution to increase colorectal cancer (CRC) screening uptake. However, preferences for these non-invasive screening tests have not been investigated in great detail yet. The purpose of this article therefore is to elicit individuals' preferences for different non-invasive screening tests in a Dutch screening campaign context.

MATERIAL AND METHODS

We investigate preferences by means of a labeled discrete choice experiment. Data of 815 individuals, aged 55-75 years, are used in the analysis.

RESULTS

Multinomial logit model analysis showed that the combi-test is generally preferred over the blood-test and the (currently available) stool-test. Furthermore, besides the large effect of screening test type, there are significant differences in preference depending on participants' socio-demographic background. Finally, the analysis showed a significant positive effect on screening test choice for the attributes sensitivity, risk reduction, and level of evidence and a non-significant effect for the attribute unnecessary follow-up test.

CONCLUSION

Introducing new non-invasive screening tests that are based on a combination of stool and blood samples (or blood sample only) has the potential to increase CRC screening participation compared to the current standard stool-based test.

摘要

背景

引入创新的非侵入性筛查测试(例如基于粪便和血液样本或两者的测试)可能是提高结直肠癌(CRC)筛查接受率的一种解决方案。然而,对于这些非侵入性筛查测试的偏好尚未得到详细研究。因此,本文的目的是在荷兰筛查活动背景下,了解个人对不同非侵入性筛查测试的偏好。

材料与方法

我们通过标记离散选择实验来研究偏好。分析中使用了815名年龄在55 - 75岁之间个体的数据。

结果

多项logit模型分析表明,组合测试通常比血液测试和(目前可用的)粪便测试更受青睐。此外,除了筛查测试类型的重大影响外,根据参与者的社会人口背景,偏好存在显著差异。最后,分析表明,对于筛查测试选择,属性敏感性、风险降低和证据水平有显著的正向影响,而对于属性不必要的后续测试则无显著影响。

结论

与当前基于粪便的标准测试相比,引入基于粪便和血液样本组合(或仅血液样本)的新型非侵入性筛查测试有可能提高CRC筛查参与率。

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