动粒信号：Kiss 使 Knl1 融化。

Kinetochore signalling: the KIss that MELTs Knl1.

机构信息

Laboratory of Biosignaling and Therapeutics, KU Leuven Department of Cellular and Molecular Medicine, University of Leuven, B-3000 Leuven, Belgium.

出版信息

Curr Biol. 2014 Jan 20;24(2):R68-R70. doi: 10.1016/j.cub.2013.11.053.

DOI:10.1016/j.cub.2013.11.053

PMID:24456977

Abstract

Mitotic kinetochores coordinate chromosome bi-orientation and anaphase onset by serving as scaffolds for the recruitment of regulatory proteins. Three new studies reveal that multiple interaction motifs of the kinetochore protein Knl1 cooperate to assemble signaling complexes that regulate chromosome segregation.

摘要

有丝分裂的动粒通过作为招募调节蛋白的支架来协调染色体的双定向和后期起始。三项新的研究揭示了着丝粒蛋白 Knl1 的多个相互作用基序合作组装信号复合物，以调节染色体分离。