Department of Evolution and Ecology, University of California, Davis, CA 95616, USA.
Science. 2014 Feb 14;343(6172):769-72. doi: 10.1126/science.1248286. Epub 2014 Jan 23.
Comparative genomic analyses have revealed that genes may arise from ancestrally nongenic sequence. However, the origin and spread of these de novo genes within populations remain obscure. We identified 142 segregating and 106 fixed testis-expressed de novo genes in a population sample of Drosophila melanogaster. These genes appear to derive primarily from ancestral intergenic, unexpressed open reading frames, with natural selection playing a significant role in their spread. These results reveal a heretofore unappreciated dynamism of gene content.
比较基因组分析表明，基因可能起源于祖先的非基因序列。然而，这些新基因在种群内的起源和传播仍然不清楚。我们在黑腹果蝇的一个种群样本中鉴定出 142 个分离和 106 个固定的睾丸表达的新基因。这些基因似乎主要来自祖先的基因间、未表达的开放阅读框，自然选择在它们的传播中起着重要作用。这些结果揭示了基因组成的一个迄今未被认识的动态变化。
