Zhao Hang, Guo Xiurong, He Shiliang, Zeng Xin, Zhou Xinglong, Zhang Chaoliang, Hu Jing, Wu Xiaohua, Xing Zhihua, Chu Liangyin, He Yang, Chen Qianming
1] State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renminnan Road, Chengdu, Sichuan 610041, China [2] Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China [3].
1] Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China [2].
Nat Commun. 2014;5:3108. doi: 10.1038/ncomms4108.
Supramolecular self-assembly is not only one of the chemical roots of biological structure but is also drawing attention in different industrial fields. Here we study the mechanism of the formation of a complex flower-shaped supramolecular structure of pyrimido[4,5-d]pyrimidine nucleosides by dynamic light scattering, scanning electron microscopy, differential scanning calorimetry, nuclear magnetic resonance and X-ray analysis. Upon removing the hydroxyl group of sugars, different flower-shaped superstructures can be produced. These works demonstrate that complex self-assembly can indeed be attained through hierarchical non-covalent interactions of single molecules. Furthermore, chimerical structures built from molecular recognition by these monomers indicate their potential in other fields if combined with other chemical entities.
超分子自组装不仅是生物结构的化学根源之一，而且在不同的工业领域也备受关注。在此，我们通过动态光散射、扫描电子显微镜、差示扫描量热法、核磁共振和X射线分析，研究了嘧啶并[4,5-d]嘧啶核苷形成复杂花状超分子结构的机制。去除糖的羟基后，可以产生不同的花状超结构。这些研究表明，通过单分子的分级非共价相互作用确实可以实现复杂的自组装。此外，由这些单体通过分子识别构建的嵌合结构表明，如果与其他化学实体结合，它们在其他领域具有潜力。
