Nucci Marta, Poon Leona C, Demirdjian Gaiane, Darbouret Bruno, Nicolaides Kypros H
Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK.
Fetal Diagn Ther. 2014;36(2):106-16. doi: 10.1159/000357842. Epub 2014 Jan 23.
To compare the maternal serum concentration of placental growth factor-1 (PlGF-1) and PlGF-2 at 11-13 weeks' gestation in normal pregnancies and in those complicated by preeclampsia (PE), delivery of small for gestational age (SGA) neonates and fetal trisomies 21, 18 and 13.
Serum PlGF-1 and PlGF-2 were measured in 270 pathological pregnancies (PE, n = 80; SGA, n = 80; trisomy 21, n = 44; trisomy 18, n = 38; trisomy 13, n = 28) and 590 normal controls. The values were expressed as multiple of the median (MoM) after adjustment for maternal characteristics and corrected for adverse pregnancy outcomes and the median MoM values in each pathological pregnancy were compared to the normal group.
There were significant contributions to PlGF-1 and PlGF-2 from gestational age, smoking and racial origin. In addition, there were significant contributions to PlGF-1 from parity and method of conception. The median MoM of PlGF-1 and PlGF-2 was significantly decreased in PE (0.783 and 0.916 MoM), SGA (0.891 and 0.851 MoM), trisomy 21 (0.609 and 0.749 MoM), trisomy 18 (0.529 and 0.730 MoM) and trisomy 13 (0.373 and 0.699 MoM).
In pathological pregnancies, except SGA, the decrease in serum PlGF-1 at 11-13 weeks' gestation is more marked than the decrease in PlGF-2.
比较正常妊娠以及合并子痫前期（PE）、小于胎龄儿（SGA）新生儿分娩和胎儿21、18及13三体综合征的孕妇在妊娠11至13周时母体血清中胎盘生长因子-1（PlGF-1）和胎盘生长因子-2（PlGF-2）的浓度。
检测了270例病理妊娠（PE，80例；SGA，80例；21三体综合征，44例；18三体综合征，38例；13三体综合征，28例）和590例正常对照者的血清PlGF-1和PlGF-2。在对母体特征进行校正并针对不良妊娠结局进行校正后，将这些值表示为中位数倍数（MoM），并将每个病理妊娠组的中位数MoM值与正常组进行比较。
胎龄、吸烟和种族对PlGF-1和PlGF-2有显著影响。此外，产次和受孕方式对PlGF-1有显著影响。PE组（0.783和0.916 MoM）、SGA组（0.891和0.851 MoM）、21三体综合征组（0.609和0.749 MoM）、18三体综合征组（0.529和0.730 MoM）和13三体综合征组（0.373和0.699 MoM）中PlGF-1和PlGF-2的中位数MoM显著降低。
在病理妊娠中，除SGA外，妊娠11至13周时血清PlGF-1的降低比PlGF-2的降低更明显。
