Wan-Yin Shi, Ming-Hua Li, Lei Yan, Yue-Qi Zhu, Jian-Ping Gu
Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, Shanghai, China
Vascular. 2014 Dec;22(6):432-8. doi: 10.1177/1708538113519443. Epub 2014 Jan 23.
This study evaluates the efficacy of dual Willis covered stents for the treatment of large fusiform carotid aneurysms in a canine model. Carotid fusiform aneurysms >10 mm long were surgically created in 10 dogs and were then repaired using either single or dual covered stents. Clinical results were assessed by scheduled angiography and histological features by light and electron microscopy. Angiography immediately post-op and 6 months after surgery revealed aneurysm isolation rates of 60 and 20% for the single stent technique and 60 and 100% for the dual stent technique, respectively. The rate of complete obliteration of the aneurysm sac differed significantly between treatments (P = 0.048). The dual stent technique also resulted in greater endothelialization. For large carotid fusiform aneurysms in a canine model, endovascular repair using dual Willis covered stents is technically feasible and more effectively obliterates the aneurysm sac than the use of a single stent.
本研究评估双Willis覆膜支架在犬模型中治疗大型梭形颈动脉动脉瘤的疗效。在10只犬中手术制造长度大于10 mm的颈动脉梭形动脉瘤，然后使用单枚或双枚覆膜支架进行修复。通过定期血管造影评估临床结果，通过光镜和电镜观察组织学特征。术后即刻及术后6个月的血管造影显示，单支架技术的动脉瘤隔绝率分别为60%和20%，双支架技术的动脉瘤隔绝率分别为60%和100%。治疗之间动脉瘤囊完全闭塞率差异有统计学意义（P = 0.048）。双支架技术还导致更大程度的内皮化。对于犬模型中的大型颈动脉梭形动脉瘤，使用双Willis覆膜支架进行血管内修复在技术上是可行的，并且比使用单支架更有效地闭塞动脉瘤囊。
