Yuan Gang, Zhu Bing
Life Science College, Beijing Normal University, Beijing, 100875, China; National Institute of Biological Sciences, Beijing, 102206, China.
National Institute of Biological Sciences, Beijing, 102206, China.
Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):222-229. doi: 10.1016/j.bbagrm.2011.06.007.
Nucleosome particles, which are composed of core histones and DNA, are the basic unit of eukaryotic chromatin. Histone modifications and histone composition determine the structure and function of the chromatin; this genome packaging, often referred to as "epigenetic information", provides additional information beyond the underlying genomic sequence. The epigenetic information must be transmitted from mother cells to daughter cells during mitotic division to maintain the cell lineage identity and proper gene expression. However, the mechanisms responsible for mitotic epigenetic inheritance remain largely unknown. In this review, we focus on recent studies regarding histone variants and discuss the assembly pathways that may contribute to epigenetic inheritance. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
核小体颗粒由核心组蛋白和DNA组成，是真核染色质的基本单位。组蛋白修饰和组蛋白组成决定了染色质的结构和功能；这种基因组包装，通常被称为“表观遗传信息”，提供了潜在基因组序列之外的额外信息。表观遗传信息必须在有丝分裂过程中从母细胞传递到子细胞，以维持细胞谱系身份和正确的基因表达。然而，负责有丝分裂表观遗传遗传的机制在很大程度上仍然未知。在这篇综述中，我们关注关于组蛋白变体的最新研究，并讨论可能有助于表观遗传遗传的组装途径。本文是名为：组蛋白伴侣与染色质组装的特刊的一部分。
