Das Madhurima, Sundell Inger Birgitta, Koka Prasad S
Department of Virology and Immunology, Haffkine Institute, Parel, Mumbai, India.
J Stem Cells. 2013;8(1):1-16.
Recent advances in the field of regenerative medicines manifested the unique properties of stem cells including the ability of self-renewal and differentiation to make them available for their replacement in tissue injury. Mesenchymal stem cells (MSCs) are important tools in treating immune disorders and in tissue repair due to their multipotency, immunosuppressive properties, and production of cytokines or growth factors. MSC-mediated therapy is a fast-growing field that has proven safe and effective in the treatment of various degenerative diseases and tissue injuries. Generation of induced pluripotent stem (iPS) cells holds a great promise for regenerative medicine and other aspects of clinical applications. The mechanisms governing multipotency in MSCs are not well understood. This review mainly throws light on the biology of MSCs, including their efficiency in treating several diseases and also the progress of the use of iPSC-derived MSC widely in the clinic.
再生医学领域的最新进展彰显了干细胞的独特特性，包括自我更新和分化能力，使其可用于组织损伤的替代治疗。间充质干细胞（MSCs）因其多能性、免疫抑制特性以及细胞因子或生长因子的分泌，成为治疗免疫紊乱和组织修复的重要工具。MSC介导的治疗是一个快速发展的领域，已被证明在治疗各种退行性疾病和组织损伤方面安全有效。诱导多能干细胞（iPS）的产生为再生医学及其他临床应用领域带来了巨大希望。目前对MSCs多能性的调控机制尚不完全清楚。本综述主要阐述了MSCs的生物学特性，包括其治疗多种疾病的功效，以及iPSC来源的MSCs在临床广泛应用的进展。
