Department of Microbiology, PRIST University, Thanjavur, Tamil Nadu, India.
Pol J Microbiol. 2013;62(3):327-30.
Burkholderia cepacia is an opportunistic pathogen causing infections in patients with cystic fibrosis. Patients with implanted devices are prone to B. cepacia infections due to its ability to grow as biofilms. Knowing the importance of polysaccharides in a biofilm, enzymes that degrade them were targeted as a possible candidate for antibiofilm agents. In this study, the antibiofilm potential of cellulase against B. cepacia biofilms formed on various prosthetic materials was tested. Cellulase exhibited significant antibiofilm activity against B. cepacia without having much action on its growth, thus ruling out the chance of selection pressure and subsequent development resistance.
洋葱伯克霍尔德菌是一种机会致病菌，可导致囊性纤维化患者发生感染。由于其能够形成生物膜，因此植入装置的患者容易发生洋葱伯克霍尔德菌感染。鉴于多糖在生物膜中的重要性，人们将能够降解它们的酶作为抗生物膜剂的候选物。本研究测试了纤维素酶对各种义体材料上形成的洋葱伯克霍尔德菌生物膜的抗生物膜潜力。纤维素酶对洋葱伯克霍尔德菌表现出显著的抗生物膜活性，而对其生长的作用不大，从而排除了选择压力和随后产生耐药性的可能性。
