Ren Yingchuan, Qi Peiyan, Li Yuxia, Wang Xiaosheng, Du Ying
Department of Otolaryngology-Head and Neck Surgery, the First Peoples' Hospital of Ping-dingshan, Pingdingshan, 467000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Sep;27(18):986-8.
To study the expression and significance of hMSH2 protein in laryngeal squamous cell carcinoma.
The expression of hMSH2 protein were detected by immunohistochemistry SP method in 51 cases of laryngeal squamous cell carcinoma, the control group included 30 cases of atypical hyperplasia tissue of vocal fold and 16 cases of normal laryngeal tissue.
The expression rates of hMSH2 in laryngeal squamous cell carcinoma, atypical hyperplasia tissue of vocal fold and normal laryngeal tissue were 58.8%, 73.3%, 87.5% respectively. There was significant difference among them (P < 0. 05). The expression of hMSH2 in laryngeal carcinoma was not associated with location and T stage (P > 0.05), but the expression was related with metastasis of lymph node and differentiation level (P < 0.05).
The deletion of hMSH2 maybe participate the early occurrence of laryngeal carcinoma; hMSH2 protein maybe delay and suppress oncogenesis and development of laryngeal carcinoma.
研究hMSH2蛋白在喉鳞状细胞癌中的表达及意义。
采用免疫组织化学SP法检测51例喉鳞状细胞癌组织中hMSH2蛋白的表达，对照组包括30例声带非典型增生组织和16例正常喉组织。
hMSH2在喉鳞状细胞癌、声带非典型增生组织及正常喉组织中的表达率分别为58.8%、73.3%、87.5%，三者之间差异有统计学意义（P < 0.05）。hMSH2在喉癌中的表达与肿瘤部位及T分期无关（P > 0.05），但与淋巴结转移及分化程度有关（P < 0.05）。
hMSH2缺失可能参与喉癌的早期发生；hMSH2蛋白可能延缓并抑制喉癌的发生发展。
