Milne E N, Zerhouni E A
Department of Radiological Sciences, University of California, Orange 92668.
J Thorac Imaging. 1987 Oct;2(4):15-23. doi: 10.1097/00005382-198710000-00005.
There is a widely held belief that metastases to the lung (like primary lung tumors) are supplied by the bronchial arteries and that pulmonary neovascularization does not occur. In 17 human lungs, we have demonstrated, both in vitro and in vivo, pulmonary circulation to metastases. We have confirmed this in a series of animal studies in which we implanted tumors of various histologies into rats' tails and induced metastases from these tumors into the lungs. Forty-eight percent of these metastases had an entirely pulmonary circulation, 36% a primarily pulmonary circulation with a small bronchial component, and only 16% of metastases, located in the central one third of the lung, had an exclusively bronchial circulation. We have now shown that these supplying pulmonary vessels to metastases can be clearly demonstrated on thin-section computed tomography of the lungs. This may prove to be a helpful, noninterventional diagnostic criterion for distinguishing a primary from a metastatic lesion.
人们普遍认为，肺转移瘤（与原发性肺肿瘤一样）由支气管动脉供血，且不会发生肺内新生血管形成。在17例人肺中，我们已在体外和体内证实了转移瘤的肺循环。我们在一系列动物研究中证实了这一点，在这些研究中，我们将各种组织学类型的肿瘤植入大鼠尾部，并诱导这些肿瘤转移至肺部。这些转移瘤中，48%有完全的肺循环，36%主要为肺循环且有少量支气管成分，仅16%位于肺中央三分之一的转移瘤有单纯的支气管循环。我们现已表明，在肺部薄层计算机断层扫描上可以清楚地显示这些为转移瘤供血的肺血管。这可能被证明是区分原发性病变和转移性病变的一种有用的非介入性诊断标准。
