Zhang Bin, Hao Guang-Yu, Gao Fang, Zhang Jian-Zu, Zhou Cheng-Jiang, Zhou Li-She, Wang Ying, Jia Yan-Bin
School of Basic Medicine, Baotou Medical College, Baotou, China E-mail :
Asian Pac J Cancer Prev. 2013;14(12):7355-8. doi: 10.7314/apjcp.2013.14.12.7355.
Several lines of evidence support the notion that MUC1 is often aberrantly expressed in gastric cancer, and it is a ligand for Helicobacter pylori. Genetic variation in MUC1 gene may confer susceptibility to H. pylori infection and gastric cancer. We assessed the association of common polymorphisms in MUC1 gene with H. pylori infection and non-cardia gastric cancer using an LD-based tag SNP approach in north-western Chinese Han population. A total of four SNPs were successfully genotyped among 288 patients with non-cardia gastric cancer and 281 age- and sex-matched controls. None of the tested SNPs was associated with H. pylori infection. SNP rs9426886 was associated with a decreased risk of non-cardia gastric cancer, but lost significance after adjustment for multiple testing. Overall, our data indicated that common genetic variations in MUC1 gene might not make a major contribution to the risk of H. pylori infection and non-cardia gastric cancer in our studied population.
MUC1在胃癌中常异常表达，且它是幽门螺杆菌的配体。MUC1基因的遗传变异可能使人易患幽门螺杆菌感染和胃癌。我们在中国西北汉族人群中采用基于连锁不平衡的标签单核苷酸多态性（SNP）方法，评估了MUC1基因常见多态性与幽门螺杆菌感染及非贲门胃癌的关联。在288例非贲门胃癌患者和281例年龄及性别匹配的对照中，成功对总共4个SNP进行了基因分型。所检测的SNP均与幽门螺杆菌感染无关。SNP rs9426886与非贲门胃癌风险降低相关，但在多重检验校正后失去显著性。总体而言，我们的数据表明，在我们的研究人群中，MUC1基因的常见遗传变异可能对幽门螺杆菌感染和非贲门胃癌的风险没有重大影响。
