Roman-Urrestarazu Andres, Murray Graham K, Barnes Anna, Miettunen Jouko, Jääskeläinen Erika, Mäki Pirjo, Nikkinen Juha, Remes Jukka, Mukkala Sari, Koivukangas Jenni, Heinimaa Markus, Moilanen Irma, Suckling John, Kiviniemi Vesa, Jones Peter B, Veijola Juha
Department of Psychiatry, University of Cambridge, Cambridge, UK.
Department of Psychiatry, University of Cambridge, Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Schizophr Res. 2014 Mar;153(1-3):143-9. doi: 10.1016/j.schres.2013.12.019. Epub 2014 Jan 24.
We tested the hypothesis that family risk for psychosis (FR) and clinical risk for psychosis (CR) are associated with structural brain abnormalities, with increased deficits in those at both family risk and clinical risk for psychosis (FRCR). The study setting was the Oulu Brain and Mind Study, with subjects drawn from the Northern Finland 1986 Birth Cohort (n=9479) using register and questionnaire based screening, and interviews using the Structured Interview for Prodromal Symptoms. After this procedure, 172 subjects were included in the study, classified as controls (n=73) and three risk groups: FR excluding CR (FR, n=60), CR without FR (CR, n=26), and individuals at both FR and CR (FRCR, n=13). T1-weighted brain scans were acquired and processed in a voxel-based analysis using permutation-based statistics. In the comparison between FRCR versus controls, we found lower grey matter volume (GMV) in a cluster (1689 voxels at -4.00, -72.00, -18.00mm) covering both cerebellar hemispheres and the vermis. This cluster was subsequently used as a mask to extract mean GMV in all four groups: FR had a volume intermediate between controls and FRCR. Within FRCR there was an association between cerebellar cluster brain volume and motor function. These findings are consistent with an evolving pattern of cerebellar deficits in psychosis risk with the most pronounced deficits in those at highest risk of psychosis.
精神病家族风险（FR）和精神病临床风险（CR）与大脑结构异常相关，且精神病家族风险和临床风险均高的个体（FRCR）的缺陷会增加。研究背景为奥卢脑与心智研究，研究对象来自芬兰北部1986年出生队列（n = 9479），通过基于登记册和问卷的筛查以及使用前驱症状结构化访谈进行招募。经过此程序，172名受试者被纳入研究，分为对照组（n = 73）和三个风险组：排除CR的FR（FR，n = 60）、无FR的CR（CR，n = 26）以及同时具有FR和CR的个体（FRCR，n = 13）。使用基于排列的统计方法，通过基于体素的分析获取并处理了T1加权脑扫描图像。在FRCR与对照组的比较中，我们发现一个覆盖小脑半球和蚓部的簇（位于-4.00，-72.00，-18.00mm处共1689个体素）中的灰质体积（GMV）较低。随后，该簇被用作掩码以提取所有四组的平均GMV：FR的体积介于对照组和FRCR之间。在FRCR组中，小脑簇脑体积与运动功能之间存在关联。这些发现与精神病风险中小脑缺陷的演变模式一致，在精神病风险最高的个体中缺陷最为明显。
