Jukuri Tuomas, Kiviniemi Vesa, Nikkinen Juha, Miettunen Jouko, Mäki Pirjo, Mukkala Sari, Koivukangas Jenni, Nordström Tanja, Moilanen Irma, Barnett Jennifer H, Jones Peter B, Murray Graham K, Veijola Juha
Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland; Department of Psychiatry, Oulu University Hospital, Finland; Thule Doctoral Programme, University of Oulu, Finland.
Department of Diagnostic Radiology, MIPT, Oulu University Hospital, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland.
Schizophr Res. 2015 Dec;169(1-3):46-53. doi: 10.1016/j.schres.2015.10.010. Epub 2015 Oct 30.
The cerebellum plays a critical role in cognition and behavior. Altered function of the cerebellum has been related to schizophrenia and psychosis but it is not known how this applies to spontaneous resting state activity in young people with familial risk for psychosis.
We conducted resting-state functional MRI (R-fMRI) in 72 (29 male) young adults with a history of psychosis in one or both parents (FR) but without their own psychosis, and 72 (29 male) similarly healthy control subjects without parental psychosis. Both groups in the Oulu Brain and Mind Study were drawn from the Northern Finland Birth Cohort 1986. Participants were 20-25 years old. Parental psychosis was established using the Care Register for Health Care. R-fMRI data pre-processing was conducted using independent component analysis with 30 and 70 components. A dual regression technique was used to detect between-group differences in the cerebellum with p<0.05 threshold corrected for multiple comparisons.
FR participants demonstrated statistically significantly increased activity compared to control subjects in the anterior lobe of the right cerebellum in the analysis with 70 components. The volume of the increased activity was 73 mm(3). There was no difference between the groups in the analysis with 30 components.
The finding suggests that increased activity of the anterior lobe of the right cerebellum may be associated with increased vulnerability to psychosis. The finding is novel, and needs replication to be confirmed.
小脑在认知和行为中起关键作用。小脑功能改变与精神分裂症和精神病有关，但尚不清楚这如何适用于有精神病家族风险的年轻人的自发静息状态活动。
我们对72名（29名男性）有父母一方或双方有精神病病史（家族风险组）但自身无精神病的年轻成年人以及72名（29名男性）同样健康且父母无精神病的对照受试者进行了静息态功能磁共振成像（R-fMRI）。奥卢脑与心智研究中的两组受试者均来自1986年芬兰北部出生队列。参与者年龄在20 - 25岁之间。通过医疗保健护理登记册确定父母是否患有精神病。使用具有30和70个成分的独立成分分析对R-fMRI数据进行预处理。采用双重回归技术检测小脑组间差异，经多重比较校正后p<0.05为阈值。
在70个成分的分析中，与对照受试者相比，家族风险组参与者右侧小脑前叶的活动在统计学上显著增加。增加活动的体积为73立方毫米。在30个成分的分析中，两组之间没有差异。
该发现表明右侧小脑前叶活动增加可能与精神病易感性增加有关。这一发现是新颖的，需要重复验证以确认。
