糖尿病老年患者血清离子镁。

Serum ionized magnesium in diabetic older persons.

机构信息

Geriatric Unit, Dept. of Internal Medicine and Specialties, University of Palermo, Italy.

出版信息

Metabolism. 2014 Apr;63(4):502-9. doi: 10.1016/j.metabol.2013.12.003. Epub 2013 Dec 16.

DOI:10.1016/j.metabol.2013.12.003

PMID:24462317

Abstract

OBJECTIVE

Several alterations of magnesium metabolism have been associated with type 2 diabetes pathophysiology, a condition particularly frequent in older persons. We aimed to evaluate serum total (Mg-tot) and serum ionized magnesium (Mg-ion) in older persons with type 2 diabetes in order to explore clinically applicable methods for the detection of magnesium deficit.

MATERIAL/METHODS: Mg-tot and Mg-ion were measured in 105 fasting subjects with type 2 diabetes (mean age: 71.1±0.8 years; M/F: 45/60) and in 100 age-matched non-diabetic control persons (mean age: 72.2±0.8 years; M/F: 42/58).

RESULTS

Mg-ion concentrations were significantly lower in diabetic persons compared with controls (0.49±0.05 mmol/L vs. 0.55±0.05 mmol/L; p<0.001). Mg-tot was also slightly but significantly lower in diabetic patients (0.82±0.007 mmol/L vs. 0.84±0.006 mmol/L; p<0.05). There was an almost complete overlap in the values of Mg-tot in older diabetic patients and controls; conversely, 44.8% of diabetic patients had Mg-ion values below 0.47 mmol/L, while none of the controls did. After adjustment for age, sex, BMI, and triglycerides, Mg-tot was significantly associated with FBG in all the participants (p<0.05) and Mg-ion was significantly associated with FBG in all the participants (p<0.01) and with HbA1c in diabetic participants (p<0.001).

CONCLUSIONS

Alterations of magnesium serum concentrations are common in type 2 diabetic older adults; Mg-ion evaluation may help to identify subclinical magnesium depletion (i.e. in patients with normal Mg-tot); the close independent associations of Mg-tot and Mg-ion with FBG and with HbA1c reinforce the possible link between magnesium homeostasis and altered glucose metabolism.

摘要

目的

已有多项研究表明镁代谢的改变与 2 型糖尿病的病理生理学有关，这种疾病在老年人中尤为常见。我们旨在评估老年 2 型糖尿病患者的血清总镁（Mg-tot）和血清离子镁（Mg-ion），以探索用于检测镁缺乏的临床适用方法。

材料/方法：我们检测了 105 例空腹 2 型糖尿病患者（平均年龄：71.1±0.8 岁；男/女：45/60）和 100 例年龄匹配的非糖尿病对照者（平均年龄：72.2±0.8 岁；男/女：42/58）的 Mg-tot 和 Mg-ion。

结果

与对照组相比，糖尿病患者的 Mg-ion 浓度显著降低（0.49±0.05 mmol/L 比 0.55±0.05 mmol/L；p<0.001）。Mg-tot 也略有但显著降低（0.82±0.007 mmol/L 比 0.84±0.006 mmol/L；p<0.05）。老年糖尿病患者和对照组的 Mg-tot 值几乎完全重叠；相反，44.8%的糖尿病患者的 Mg-ion 值低于 0.47 mmol/L，而对照组则没有。在校正年龄、性别、BMI 和甘油三酯后，Mg-tot 在所有参与者中与 FBG 显著相关（p<0.05），Mg-ion 在所有参与者中与 FBG 显著相关（p<0.01），在糖尿病患者中与 HbA1c 显著相关（p<0.001）。