Gürlek A, Bayraktar M, Ozaltin N
Department of Endocrinology and Metabolism, Haceteppe University School of Medicine, Ankara, Turkey.
Horm Metab Res. 1998 Feb;30(2):99-102. doi: 10.1055/s-2007-978844.
We investigated whether erythrocyte magnesium (Mg) depletion exists in subjects with Type I diabetes. To this end, Mg levels in plasma, erythrocytes and urine were determined in 12 patients with Type I diabetes and compared with 12 healthy control subjects. Mean plasma Mg concentrations were comparable between diabetic patients and control subjects (0.90 +/- 0.29 mmol/l vs 1.04 +/- 0.14 mmol/l, respectively; p = 0.16). Mean erythrocyte Mg concentration was significantly lower in the diabetic group compared with the control group (1.41 +/- 0.56 mmol/l vs. 2.94 +/- 1.13 mmol/l, respectively; p < 0.0001). Mean urine Mg excretion was significantly elevated in the diabetic group with respect to the controls (6.86 +/- 3.5 mmol/g creatinine/24 h vs. 4.03 +/- 1.65 mmol/g creatinine/24 h, respectively; p = 0.02). As to the diabetic group, erythrocyte Mg concentration showed a significant inverse correlation with urine Mg excretion (r = -0.58, p = 0.049). There was no correlation between urine Mg concentration and glycosylated hemoglobin or fasting plasma glucose level. The data suggest that intracellular Mg depletion without significant hypomagnesemia is related to increased urinary Mg loss in patients with Type I diabetes. The urinary Mg loss is not correlated with the degree of metabolic control.
我们研究了1型糖尿病患者是否存在红细胞镁（Mg）缺乏。为此，测定了12例1型糖尿病患者血浆、红细胞和尿液中的镁水平，并与12名健康对照者进行比较。糖尿病患者和对照者的平均血浆镁浓度相当（分别为0.90±0.29 mmol/L和1.04±0.14 mmol/L；p = 0.16）。糖尿病组的平均红细胞镁浓度显著低于对照组（分别为1.41±0.56 mmol/L和2.94±1.13 mmol/L；p < 0.0001）。糖尿病组的平均尿镁排泄相对于对照组显著升高（分别为6.86±3.5 mmol/g肌酐/24小时和4.03±1.65 mmol/g肌酐/24小时；p = 0.02）。对于糖尿病组，红细胞镁浓度与尿镁排泄呈显著负相关（r = -0.58，p = 0.049）。尿镁浓度与糖化血红蛋白或空腹血糖水平之间无相关性。数据表明，1型糖尿病患者细胞内镁缺乏但无明显低镁血症与尿镁丢失增加有关。尿镁丢失与代谢控制程度无关。
