Resnick L M, Altura B T, Gupta R K, Laragh J H, Alderman M H, Altura B M
Cardiovascular Center, New York Hospital-Cornell Medical Center, New York.
Diabetologia. 1993 Aug;36(8):767-70. doi: 10.1007/BF00401149.
To investigate alterations of magnesium metabolism in Type 2 (non-insulin-dependent) diabetes mellitus, we utilized a new magnesium-specific selective ion electrode apparatus to measure serum ionized magnesium (Mg-io) in fasting subjects with and without Type 2 diabetes, and compared these values to levels of serum total magnesium, and of intracellular free magnesium (Mgi) analysed by 31P-NMR spectroscopy. Both Mg-io (0.630 +/- 0.008 vs 0.552 +/- 0.008 mmol/l, p < 0.001) and Mgi (223.3 +/- 8.3 vs 184 +/- 13.7 mmol/l, p < 0.001), but not serum total magnesium, were significantly reduced in Type 2 diabetes compared with non-diabetic control subjects. Furthermore, a close relationship was observed between serum Mg-io and Mgi (r = 0.728, p < 0.001). We suggest that magnesium deficiency, both extracellular and intracellular, is a characteristic of chronic stable mild Type 2 diabetes, and as such, may predispose to the excess cardiovascular morbidity of the diabetic state. Furthermore, by more adequately reflecting cellular magnesium metabolism than total serum magnesium levels, Mg-io measurements may provide a more readily available tool than has heretofore been available to analyse magnesium metabolism in a variety of diseases.
为研究2型（非胰岛素依赖型）糖尿病患者镁代谢的变化，我们使用一种新型镁特异性选择性离子电极仪，测量了患有和未患2型糖尿病的空腹受试者的血清离子化镁（Mg-io），并将这些值与血清总镁水平以及通过31P-NMR光谱分析的细胞内游离镁（Mgi）水平进行比较。与非糖尿病对照受试者相比，2型糖尿病患者的Mg-io（0.630±0.008 vs 0.552±0.008 mmol/l，p<0.001）和Mgi（223.3±8.3 vs 184±13.7 mmol/l，p<0.001）均显著降低，但血清总镁水平未降低。此外，观察到血清Mg-io与Mgi之间存在密切关系（r = 0.728，p<0.001）。我们认为，细胞外和细胞内的镁缺乏是慢性稳定轻度2型糖尿病的一个特征，因此可能是糖尿病状态下心血管疾病发病率过高的原因。此外，与血清总镁水平相比，Mg-io测量能更充分地反映细胞镁代谢，可能为分析多种疾病中的镁代谢提供一种比以往更便捷的工具。
