Green Holly F, Nolan Yvonne M
Department of Anatomy and Neuroscience, University College Cork, Ireland.
Neurosci Biobehav Rev. 2014 Mar;40:20-34. doi: 10.1016/j.neubiorev.2014.01.004. Epub 2014 Jan 21.
While the detrimental impact of inflammation on adult hippocampal neurogenesis and associated behaviors has recently gained credence, the effects of inflammation on the developing brain is an area of research which is quickly gaining momentum, and a growing number of research articles on this topic have been published in recent years. Indeed, we now know that pro-inflammatory mediators negatively influence both hippocampal neurogenesis and neuronal cytoarchitecture during brain development. Here we present a comprehensive review of the current literature on inflammation-induced changes in hippocampal neurogenesis during early life and the consequent behavioral deficits which may ensue in later life. We also offer insights into the cellular and molecular mechanisms underlying the hippocampal-dependant behavioral changes observed in neurodevelopmental disorders, particularly in those where cognitive dysfunction plays a major role. We further consider whether early-life inflammation-induced changes in hippocampal neurogenesis may contribute to the onset of mood and cognitive deficits in later life.
虽然炎症对成体海马神经发生及相关行为的有害影响最近已得到认可，但炎症对发育中大脑的影响是一个正在迅速发展的研究领域，近年来关于该主题的研究文章越来越多。事实上，我们现在知道促炎介质在大脑发育过程中对海马神经发生和神经元细胞结构均有负面影响。在此，我们全面综述了当前关于生命早期炎症诱导的海马神经发生变化以及随后可能在后期出现的行为缺陷的文献。我们还深入探讨了神经发育障碍中观察到的海马依赖性行为变化背后的细胞和分子机制，特别是在那些认知功能障碍起主要作用的疾病中。我们进一步思考生命早期炎症诱导的海马神经发生变化是否可能导致后期情绪和认知缺陷的发生。
