Debeljuk L, Lasaga M, Horvath J, Duvilanski B H, Seilicovich A, Díaz M C
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Regul Pept. 1987 Oct;19(1-2):91-8. doi: 10.1016/0167-0115(87)90078-4.
The effects of the acute injection of a rabbit anti-substance P serum (ASPS) were studied in normal rats and rats with hyperprolactinemia induced by 5-hydroxytryptophan and estradiol given as a short or chronic treatment. The anti-substance P serum decreased the release of prolactin induced by 5-hydroxytryptophan when this serotonin precursor was injected 24 h, but not 1 h, after the administration of the antiserum. ASPS reduced the hyperprolactinemia induced by short and chronic treatment with estradiol in castrated rats. This effect was observed 24 h after the injection of the antiserum. On the other hand, the injection of ASPS induced a significant decrease in LH levels in serum of intact male rats injected with 5-hydroxytryptophan 24 h after ASPS, and in castrated rats treated with short-term and chronic administration of estradiol, 24 h after the injection of the antiserum. These results suggest that substance P may have a role in the control of prolactin secretion and could play a part in the hyperprolactinemic effects of estradiol. On the other hand, substance P, under certain circumstances, may stimulate LH release.
研究了急性注射兔抗P物质血清（ASPS）对正常大鼠以及经短期或长期给予5-羟色氨酸和雌二醇诱导产生高催乳素血症大鼠的影响。当在注射抗血清24小时而非1小时后注射这种血清素前体5-羟色氨酸时，抗P物质血清会降低其诱导的催乳素释放。ASPS可降低去势大鼠经短期和长期雌二醇处理所诱导的高催乳素血症。在注射抗血清24小时后可观察到这种效果。另一方面，在注射ASPS 24小时后，给完整雄性大鼠注射5-羟色氨酸，以及给经短期和长期雌二醇处理的去势大鼠注射抗血清24小时后，注射ASPS会导致血清中LH水平显著降低。这些结果表明，P物质可能在催乳素分泌的控制中发挥作用，并且可能参与雌二醇的高催乳素血症效应。另一方面，在某些情况下，P物质可能会刺激LH释放。
