Centre de Recherche Entomologique de Cotonou (CREC), Ministère de la Santé, Cotonou 06 BP 2604, Bénin.
Trans R Soc Trop Med Hyg. 2014 Feb;108(2):84-91. doi: 10.1093/trstmh/trt117.
Using the same insecticide for multiple successive indoor residual spraying (IRS) cycles is not recommended; instead, the National Malaria Control Program (NMCP) has decided to select another insecticide (insecticide B) in addition to bendiocarb for indoor residual spraying.
An experimental hut trial comparing the effectiveness of three classes of insecticides (one carbamate [bendiocarb], two organophosphates [fenitrothion and pirimiphos methyl] and one pyrethroid [lambdacyalothrin]) was conducted in Malanville, northern Benin, against wild free entered resistant Anopheles gambiae s.l. population to pyrethroids.
Fenitrothion and pirimiphos methyl yielded the highest rate of deterrence. Their mean rates were respectively 46.6% and 35.4%. Regarding blood feeding inhibition, only fenitrothion has induced a significant inhibition rate (25.4% as mean rate). As regards the exophily rates, only lambdacyhalothrin has induced the highest rate (39.7%). Pirimiphos methyl showed the highest mortality rate and also induced a mortality rate of at least 80% in blood fed An. gambiae population after 24 h observation time. Furthermore, the huts treated with pirimiphos methyl showed the highest residual effect, followed by lambdacyhalothrin.
Benin NMCP has selected pirimiphos methyl as insecticide B to alternate or combine to bendiocarb (carbamate) because of the adverse effects of fenitrothion on the sleepers and its short residual effect on walls.
不建议在多个连续的室内滞留喷洒（IRS）周期中使用相同的杀虫剂；相反，国家疟疾控制规划（NMCP）已决定除了苯氧威之外，还选择另一种杀虫剂（杀虫剂 B）用于室内滞留喷洒。
在贝宁北部马兰维尔进行了一项实验性小屋试验，比较了三类杀虫剂（一种氨基甲酸酯[苯氧威]、两种有机磷[fenitrothion 和 pirimiphos methyl]和一种拟除虫菊酯[lambdacyalothrin]）对野外自由进入的抗拟除虫菊酯的冈比亚按蚊种群的效果。
fenitrothion 和 pirimiphos methyl 产生了最高的驱避率。它们的平均驱避率分别为 46.6%和 35.4%。关于吸血抑制，只有 fenitrothion 诱导了显著的抑制率（平均抑制率为 25.4%）。至于外生性率，只有 lambdacyhalothrin 诱导了最高的率（39.7%）。pirimiphos methyl 表现出最高的死亡率，并且在 24 小时观察时间后，在喂食血液的 An. gambiae 种群中也诱导了至少 80%的死亡率。此外，用 pirimiphos methyl 处理的小屋表现出最高的残留效果，其次是 lambdacyhalothrin。
由于 fenitrothion 对睡眠者的不利影响及其对墙壁的短残留效果，贝宁 NMCP 已选择 pirimiphos methyl 作为杀虫剂 B 来替代或与苯氧威（氨基甲酸酯）联合使用。
