Bohdanowicz-Pawlak Anna, Szymczak Jadwiga, Jakubowska Joanna, Jedrzejuk Diana, Pawlak Andrzej, Lukienczuk Tadeusz, Bolanowski Marek
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University Wroclaw, Poland.
Department of Orthopedics, Specialist Hospital, Wrocław, Poland.
Neuro Endocrinol Lett. 2013;34(7):610-4.
Brown tumors are rare skeletal manifestations of hyperparathyroidism (HPT) that may mimic cancer metastases. Histopathologically, they are difficult to differentiate from other giant cell lesions. A case is presented of 41-year-old woman with giant cell tumor in parieto-occipital region with injury of external bone lamina, growing into the skull cavity. The mass was suspected of being neoplastic. Numerous osteolytic lesions in the skull skeleton and multifocal bone injuries were observed, also. Elevation in calcium (5.91 mEq/L) and parathormone (1188 ng/mL) concentrations and hypercalciuria (52 mEq/24 h) suggested the diagnosis of HPT initially manifesting as a brown tumor of the skull. Further exploration confirmed the existence of parathyroid adenoma as a cause of the disease. The key treatment for the condition was surgical excision of the adenoma followed by the normalization of parathyroid function and significant reduction in size of skull tumor and other lesions.
棕色瘤是甲状旁腺功能亢进症（HPT）罕见的骨骼表现，可能酷似癌症转移。在组织病理学上，它们很难与其他巨细胞病变区分开来。本文报告一例41岁女性，其顶枕部患有巨细胞瘤，伴有外骨板损伤，并向颅腔生长。该肿块被怀疑是肿瘤性的。还观察到颅骨骨骼中有许多溶骨性病变和多灶性骨损伤。钙浓度（5.91 mEq/L）和甲状旁腺激素浓度（1188 ng/mL）升高以及高钙尿症（52 mEq/24 h）提示最初诊断为HPT，表现为颅骨棕色瘤。进一步检查证实存在甲状旁腺腺瘤是该疾病的病因。该疾病的关键治疗方法是手术切除腺瘤，随后甲状旁腺功能恢复正常，颅骨肿瘤和其他病变的大小显著减小。
