Hemmati Fatemeh, Ghasemi Rasoul, Mohamed Ibrahim Norlinah, Dargahi Leila, Mohamed Zahurin, Raymond Azman Ali, Ahmadiani Abolhassan
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Mol Neurobiol. 2014 Dec;50(3):797-810. doi: 10.1007/s12035-013-8631-3. Epub 2014 Jan 25.
Neuroinflammation is known as a key player in a variety of neurodegenerative and/or neurological diseases. Brain Toll-like receptors (TLRs) are leading elements in the initiation and progression of neuroinflammation and the development of different neuronal diseases. Furthermore, TLR activation is one of the most important elements in the induction of insulin resistance in different organs such as the central nervous system. Involvement of insulin signaling dysregulation and insulin resistance are also shown to contribute to the pathology of neurological diseases. Considering the important roles of TLRs in neuroinflammation and central insulin resistance and the effects of these processes in the initiation and progression of neurodegenerative and neurological diseases, here we are going to review current knowledge about the potential crosstalk between TLRs and insulin signaling pathways in neuroinflammatory disorders of the central nervous system.
神经炎症被认为是多种神经退行性疾病和/或神经系统疾病的关键因素。脑内 Toll 样受体（TLRs）是神经炎症发生发展以及不同神经元疾病形成过程中的主要因素。此外，TLR 激活是中枢神经系统等不同器官中诱导胰岛素抵抗的最重要因素之一。胰岛素信号失调和胰岛素抵抗的参与也被证明与神经系统疾病的病理过程有关。鉴于 TLRs 在神经炎症和中枢胰岛素抵抗中的重要作用，以及这些过程在神经退行性疾病和神经系统疾病发生发展中的影响，在此我们将综述目前关于中枢神经系统神经炎症性疾病中 TLRs 与胰岛素信号通路之间潜在相互作用的相关知识。
