Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia, Boston Children's Hospital, Boston, MA, United States.
Department of Anesthesia and Immunology, Harvard Medical School, Boston, MA, United States.
Front Immunol. 2024 Jun 10;15:1403764. doi: 10.3389/fimmu.2024.1403764. eCollection 2024.
Immune system recognizes invading microbes at both pathogen and antigen levels. Toll-like receptors (TLRs) play a key role in the first-line defense against pathogens. Major functions of TLRs include cytokine and chemokine production. TLRs share common downstream signaling pathways with other receptors. The crosstalk revolving around TLRs is rather significant and complex, underscoring the intricate nature of immune system. The profiles of produced cytokines and chemokines via TLRs can be affected by other receptors. Integrins are critical heterodimeric adhesion molecules expressed on many different cells. There are studies describing synergetic or inhibitory interplay between TLRs and integrins. Thus, we reviewed the crosstalk between TLRs and integrins. Understanding the nature of the crosstalk could allow us to modulate TLR functions via integrins.
免疫系统在病原体和抗原水平上识别入侵的微生物。 Toll 样受体 (TLR) 在抵御病原体的第一线防御中起着关键作用。 TLR 的主要功能包括细胞因子和趋化因子的产生。 TLR 与其他受体共享共同的下游信号通路。 TLR 之间的串扰非常重要且复杂，突出了免疫系统的复杂性。 TLR 产生的细胞因子和趋化因子的特征可受其他受体的影响。 整合素是许多不同细胞上表达的关键异二聚体粘附分子。 有研究描述了 TLR 和整合素之间的协同或抑制相互作用。 因此，我们综述了 TLR 与整合素之间的串扰。 了解串扰的性质可以使我们能够通过整合素来调节 TLR 功能。
