Barragán Eduardo, Breuer Dieter, Döpfner Manfred
1 The Federico Gómez Children's Hospital of Mexico.
2 University Hospital Cologne, Germany.
J Atten Disord. 2017 Mar;21(5):433-441. doi: 10.1177/1087054713518239. Epub 2016 Jul 28.
To compare efficacy of Omega-3/6 fatty acids (Equazen eye q™) with methylphenidate (MPH) and combined MPH + Omega-3/6 in children with ADHD.
Participants ( N = 90) were randomized to Omega-3/6, long-acting MPH, or combination for 12 months. ADHD symptoms were assessed using the ADHD Rating Scale and Clinical Global Impressions-Severity (CGI-S) scale.
ADHD symptoms decreased in all treatment arms. Although significant differences favoring Omega + MPH over Omega-3/6 alone were found for ADHD Total and Hyperactivity-Impulsivity subscales, results on the Inattention subscale were similar. CGI-S scores decreased slowly and consistently with Omega-3/6, compared with a rapid decrease and subsequent slight increase in the MPH-containing arms. Adverse events were numerically less frequent with Omega-3/6 or MPH + Omega-3/6 than MPH alone.
The tested combination of Omega-3/6 fatty acids had similar effects to MPH, whereas the MPH + Omega combination appeared to have some tolerability benefits over MPH.
比较欧米伽-3/6脂肪酸（Equazen eye q™）与哌甲酯（MPH）以及MPH+欧米伽-3/6联合用药对多动症儿童的疗效。
90名参与者被随机分为接受欧米伽-3/6、长效MPH或联合用药治疗12个月。使用多动症评定量表和临床总体印象-严重程度（CGI-S）量表评估多动症症状。
所有治疗组的多动症症状均有所减轻。尽管在多动症总分和多动-冲动性子量表上发现欧米伽+MPH组比单独使用欧米伽-3/6组有显著差异，但在注意力不集中子量表上的结果相似。与含MPH组快速下降随后略有上升相比，CGI-S评分在欧米伽-3/6组缓慢且持续下降。欧米伽-3/6或MPH+欧米伽-3/6组的不良事件在数量上比单独使用MPH组少。
测试的欧米伽-3/6脂肪酸组合与MPH有相似效果，而MPH+欧米伽组合在耐受性方面似乎比MPH有一些优势。
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