Wang Lu, Zhang Wei, Wu Ruiyong, Kong Lingzhe, Feng Weige, Cao Yan, Tai Fadao, Zhang Xia
Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, 710062, Shaanxi, China; Key laboratory of Modern Teaching Technology, Ministry of Education, Xi'an, 710062, Shaanxi, China.
Dev Psychobiol. 2014 Sep;56(6):1214-28. doi: 10.1002/dev.21202. Epub 2014 Jan 24.
Neonatal isolation and paternal deprivation have long lasting effects on the behavior and neuroendocrine system at adulthood. Whether these effects at adulthood are induced by neonatal changes in relevant neuroendocrine parameters lead by these early-life social experiences is not well understood. Whether monogamous rodents exhibit a stress hypo-responsive period (SHRP) also remains unclear. Using the monogamous mandarin vole, we found that 30 min of isolation did not affect levels of corticosterone (CORT) and adrenocorticotropin (ACTH) at postnatal days 8, 10, and 12 displaying a SHRP, but increased these at postnatal days 4, 14, 16, and 18. Isolation increased vasopressin (AVP)-ir neurons in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) from postnatal days 4 to 12, and up-regulated oxytocin (OT)-ir neurons in the PVN at postnatal days 4 and 8 and SON at postnatal day 4. Paternally deprived pups showed increase in ACTH and CORT after 30 min of social isolation from postnatal days 8 to 14, increase in AVP-ir neurons in the PVN from postnatal days 10 to 14, reduction in OT-ir neurons in the PVN from postnatal days 10 to 14 and in the SON at postnatal days 12 and 14. These results indicate that monogamous mandarin voles display a short SHRP which can be disrupted by paternal deprivation. Central AVP and OT levels may also be altered by paternal deprivation and social isolation. We propose that changes in these neuroendocrine parameters induced by early-life social experiences such as those tested here persist and result.
新生儿隔离和父性剥夺对成年后的行为和神经内分泌系统具有长期影响。目前尚不清楚成年期的这些影响是否由这些早期社会经历导致的相关神经内分泌参数的新生儿期变化所引起。一夫一妻制啮齿动物是否表现出应激低反应期（SHRP）也仍不清楚。利用一夫一妻制的棕色田鼠，我们发现30分钟的隔离在出生后第8、10和12天（显示出SHRP）时不影响皮质酮（CORT）和促肾上腺皮质激素（ACTH）水平，但在出生后第4、14、16和18天会使其升高。从出生后第4天到12天，隔离增加了室旁核（PVN）和视上核（SON）中血管加压素（AVP）免疫反应性神经元，在出生后第4天和8天增加了PVN中催产素（OT）免疫反应性神经元，在出生后第4天增加了SON中OT免疫反应性神经元。从出生后第8天到14天，父性剥夺的幼崽在30分钟的社会隔离后ACTH和CORT增加，从出生后第10天到14天PVN中AVP免疫反应性神经元增加，从出生后第10天到14天PVN中OT免疫反应性神经元减少，在出生后第12天和14天SON中OT免疫反应性神经元减少。这些结果表明，一夫一妻制的棕色田鼠表现出短暂的SHRP，这可能会被父性剥夺所破坏。父性剥夺和社会隔离也可能改变中枢AVP和OT水平。我们提出，由早期社会经历（如此处测试的那些）诱导的这些神经内分泌参数的变化会持续存在并产生影响。
