Department of Pediatric Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
World J Pediatr. 2014 Feb;10(1):10-6. doi: 10.1007/s12519-014-0448-2. Epub 2014 Jan 25.
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and displays remarkable heterogeneity in clinical behaviors, ranging from spontaneous regression to rapid progression or resistance to multimodal treatment. Recent evidence has shown that microRNAs (miRNAs), a class of small non-coding RNAs, are involved in tumor development and progression. This article aimed to review recent advances in investigating the roles of miRNAs in NB.
We searched the PubMed/MEDLINE database for articles about the expression profile, functions and target genes of miRNAs in NB.
We reviewed the most recent evidence regarding the functional roles of oncogenic and tumor suppressive miRNAs in NB and application of novel miRNA-based methods for diagnostic, prognostic and therapeutic purposes.
Deregulation of miRNAs is associated with the development and progression of NB, suggesting that miRNAs may serve as novel targets for the treatment of high-risk NB patients. However, their precise functions and underlying mechanisms still warrant further studies.
神经母细胞瘤（NB）是儿童期最常见的颅外实体瘤，其临床行为表现出显著的异质性，从自发消退到快速进展或对多模式治疗的耐药性不等。最近的证据表明，microRNAs（miRNAs）是一类小的非编码 RNA，参与肿瘤的发生和发展。本文旨在综述 miRNAs 在 NB 中的作用的研究进展。
我们在 PubMed/MEDLINE 数据库中搜索了关于 NB 中 miRNAs 的表达谱、功能和靶基因的文章。
我们回顾了关于致癌和肿瘤抑制 miRNAs 在 NB 中的功能作用以及新型 miRNA 方法在诊断、预后和治疗目的中的应用的最新证据。
miRNAs 的失调与 NB 的发生和发展有关，这表明 miRNAs 可能成为治疗高危 NB 患者的新靶点。然而，它们的确切功能和潜在机制仍需要进一步研究。
